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Browsing by Author "Bonovas, Stefanos"

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    • Article  

      Alcohol and psychoactive drugs increased the pre-hospital mortality in 655 fall-related fatalities in Greece: A call for management protocols 

      Papadopoulos, I. N.; Bonovas, Stefanos; Kanakaris, Nikolaos K.; Nikolopoulos, Georgios K.; Kotsilianou, Olympia; Konstantoudakis, Georgios; Leukidis, Christos (2012)
      Introduction: The frequency of alcohol and psychoactive drugs in fall-related fatalities and their effect on type, severity of injury and location of death constitute the subjects of this study. Methods: A retrospective ...

    • Article  

      Antiretrovirals for HIV exposure prophylaxis 

      Nikolopoulos, Georgios K.; Tsiodras, Sotirios; Bonovas, Stefanos; Hatzakis, A. (2012)
      Infection with Human Immunodeficiency Virus (HIV) remains a global public health problem. Although the epidemic has not been completely controlled, there was considerable progress in HIV prevention and treatment during the ...

    • Article  

      Antiviral drugs in the prophylaxis of HBV infection 

      Masgala, Aikaterini; Nikolopoulos, Georgios K.; Tsiodras, Sotirios; Bonovas, Stefanos; Sitaras, N. M. (2012)
      Reactivation of hepatitis B infection (HBV) is known to occur in liver graft recipients and in chronic carriers of the surface antigen of HBV who receive immunosuppressive therapy. The use of hepatitis B immune globulin ...

    • Article  

      Antivirals used for influenza chemoprophylaxis 

      Tsiodras, Sotirios; Nikolopoulos, Georgios K.; Bonovas, Stefanos (2012)
      Current data about the role of adamantanes and neuraminidase inhibitors (NIs) in the chemoprophylaxis against influenza viruses were reviewed. We found significant evidence favouring the role of NIs in the chemoprophylaxis ...

    • Article  

      The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)
      Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...

    • Article  

      Big events in Greece and HIV infection among people who inject drugs 

      Nikolopoulos, Georgios K.; Sypsa, V.; Bonovas, Stefanos; Paraskeva, D.; Malliori-Minerva, Melpomeni; Hatzakis, A.; Friedman, Samuel R. (2015)
      Big Events are processes like macroeconomic transitions that have lowered social well-being in various settings in the past. Greece has been hit by the global crisis and experienced an HIV outbreak among people who inject ...

    • Article  

      Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis 

      Bonovas, Stefanos; Fiorino, Gionata; Allocca, Mariangela; Lytras, Theodoros; Nikolopoulos, Georgios K.; Peyrin-Biroulet, L.; Danese, Silvio (2016)
      Background & Aims Safety issues are a major concern for patients considering treatments for inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis to determine whether biologic agents affect ...

    • Article  

      Bisphosphonate use and risk of colorectal cancer: A systematic review and meta-analysis 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2013)
      Aim: A growing body of evidence suggests that bisphosphonates may have chemopreventive potential against colorectal cancer. Our aim was to examine this association through a meta-analysis of observational studies. Methods: ...

    • Article  

      Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Filioussi, K.; Peponi, Evangelia; Bagos, Pantelis G.; Sitaras, N. M. (2010)
      A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ...

    • Article  

      Commentary on pravastatin and cancer: Need for individual patient data meta-analyses 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2010)

    • Article  

      Comparative assessment of budesonide-MMX and mesalamine in active, mild-to-moderate ulcerative colitis: A systematic review and network meta-analysis 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Piovani, Daniele; González‐Lorenzo, Marien; Pantavou, Katerina; Lytras, Theodore; Peyrin‐Biroulet, Laurent; Danese, Silvio (2019)
      Aims The comparative efficacy, safety and tolerability of budesonide-MMX and oral mesalamine in active, mild-to-moderate ulcerative colitis (UC) are unclear. We conducted a network meta-analysis to fill this evidence gap. ...

    • Article  

      Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysis 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Lytras, Theodore; Fiorino, Gionata; Peyrin‐Biroulet, Laurent; Danese, Silvio (2018)
      Aims Oral systemic corticosteroids have been used to induce remission in patients with active inflammatory bowel disease (IBD) for over 50 years

    • Article  

      Comparison between Nageotte and flow cytometric counting of residual leucocytes in freshly prepared leucocyte-reduced red blood cell components 

      Nikolopoulos, Georgios K.; Kyriakou, Elias; Nearchakos, Nikolaos; Bonovas, Stefanos; Makri, Efstathia; Pantavou, Katerina; Kottaridi, Christine; Gialeraki, Argyri; Douramani, Panagiota; Taichert, Maria; Kapsimali, Violetta; Tsantes, Argirios E. (2018)
      Background Flow cytometry (FC) and Nageotte hemocytometry represent the most widely accepted methods for counting residual white blood cells (rWBCs) in leucocyte-reduced (LR) blood components. Our aim was to study the ...

    • Article  

      Condom effectiveness in reducing heterosexual HIV transmission: a systematic review and meta-analysis of studies on HIV serodiscordant couples 

      Giannou, Foteini K.; Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Talias, M.; Benetou, Vasiliki; Kantzanou, Maria; Bonovas, Stefanos; Hatzakis, A. (2016)
      Objective: This systematic review and meta-analysis aimed to reassess the effectiveness of condoms in reducing heterosexual transmission of HIV. Methods: Medline, Scopus, and the ISI Web of Science databases were searched ...

    • Article  

      Cost-effectiveness of leucoreduction for prevention of febrile non-haemolytic transfusion reactions 

      Tsantes, Argirio E.; Kyriakou, Elias; Nikolopoulos, Georgios K.; Stylos, D.; Sidhom, M.; Bonovas, Stefanos; Douramani, Panagiota; Kalantzis, Dimitrios; Kokoris, Styliani; Valsami, S.; Stamoulis, K.; Politou, M.; Foudoulaki-Paparizos, Leontini (2014)
      Background. The cost-effectiveness of universal leucoreduction of blood components remains unclear. When using leucoreduced red blood cells, the decrease in the rate of febrile non-haemolytic transfusion reactions (FNHTR) ...

    • Article  

      Developing the evidence base for cancer chemoprevention: Use of meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)
      Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

    • Article  

      An ecological study of the determinants of differences in 2009 pandemic influenza mortality rates between countries in Europe 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Lytras, Theodoros; Bonovas, Stefanos (2011)
      Background: Pandemic A (H1N1) 2009 mortality rates varied widely from one country to another. Our aim was to identify potential socioeconomic determinants of pandemic mortality and explain between-country variation. ...

    • Article  

      Editorial: evidence is growing for protective effects of 5-aminosalicylates against colitis-associated cancer—authors’ reply 

      Bonovas, Stefanos; Fiorino, Gionata; Lytras, Theodoros; Nikolopoulos, Georgios K.; Peyrin-Biroulet, L.; Danese, Silvio (2017)

    • Article  

      Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome 

      Tsantes, Argirio E.; Kopterides, Petros; Bonovas, Stefanos; Bagos, Pantelis G.; Antonakos, Georgios; Nikolopoulos, Georgios K.; Gialeraki, Argiri; Kapsimali, Violetta; Kyriakou, Elias; Kokoris, Styliani; Dima, Kleanthi; Armaganidis, Apostolos; Tsangaris, I. (2013)
      Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ...

    • Article  

      The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos; Kopterides, Petros; Vaiopoulos, G. (2008)
      Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma ...

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