Browsing by Author "Bonovas, Stefanos"

Article

Alcohol and psychoactive drugs increased the pre-hospital mortality in 655 fall-related fatalities in Greece: A call for management protocols

Papadopoulos, I. N.; Bonovas, Stefanos; Kanakaris, Nikolaos K.; Nikolopoulos, Georgios K.; Kotsilianou, Olympia; Konstantoudakis, Georgios; Leukidis, Christos (2012)

Introduction: The frequency of alcohol and psychoactive drugs in fall-related fatalities and their effect on type, severity of injury and location of death constitute the subjects of this study. Methods: A retrospective ...

Article

Antiretrovirals for HIV exposure prophylaxis

Nikolopoulos, Georgios K.; Tsiodras, Sotirios; Bonovas, Stefanos; Hatzakis, A. (2012)

Infection with Human Immunodeficiency Virus (HIV) remains a global public health problem. Although the epidemic has not been completely controlled, there was considerable progress in HIV prevention and treatment during the ...

Article

Antiviral drugs in the prophylaxis of HBV infection

Masgala, Aikaterini; Nikolopoulos, Georgios K.; Tsiodras, Sotirios; Bonovas, Stefanos; Sitaras, N. M. (2012)

Reactivation of hepatitis B infection (HBV) is known to occur in liver graft recipients and in chronic carriers of the surface antigen of HBV who receive immunosuppressive therapy. The use of hepatitis B immune globulin ...

Article

Antivirals used for influenza chemoprophylaxis

Tsiodras, Sotirios; Nikolopoulos, Georgios K.; Bonovas, Stefanos (2012)

Current data about the role of adamantanes and neuraminidase inhibitors (NIs) in the chemoprophylaxis against influenza viruses were reviewed. We found significant evidence favouring the role of NIs in the chemoprophylaxis ...

Article

The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)

Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...

Article

Big events in Greece and HIV infection among people who inject drugs

Nikolopoulos, Georgios K.; Sypsa, V.; Bonovas, Stefanos; Paraskeva, D.; Malliori-Minerva, Melpomeni; Hatzakis, A.; Friedman, Samuel R. (2015)

Big Events are processes like macroeconomic transitions that have lowered social well-being in various settings in the past. Greece has been hit by the global crisis and experienced an HIV outbreak among people who inject ...

Article

Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis

Bonovas, Stefanos; Fiorino, Gionata; Allocca, Mariangela; Lytras, Theodoros; Nikolopoulos, Georgios K.; Peyrin-Biroulet, L.; Danese, Silvio (2016)

Background & Aims Safety issues are a major concern for patients considering treatments for inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis to determine whether biologic agents affect ...

Article

Bisphosphonate use and risk of colorectal cancer: A systematic review and meta-analysis

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2013)

Aim: A growing body of evidence suggests that bisphosphonates may have chemopreventive potential against colorectal cancer. Our aim was to examine this association through a meta-analysis of observational studies. Methods: ...

Article

Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Filioussi, K.; Peponi, Evangelia; Bagos, Pantelis G.; Sitaras, N. M. (2010)

A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ...

Article

Commentary on pravastatin and cancer: Need for individual patient data meta-analyses

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2010)

Article

Comparative assessment of budesonide-MMX and mesalamine in active, mild-to-moderate ulcerative colitis: A systematic review and network meta-analysis

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Piovani, Daniele; González‐Lorenzo, Marien; Pantavou, Katerina; Lytras, Theodore; Peyrin‐Biroulet, Laurent; Danese, Silvio (2019)

Aims The comparative efficacy, safety and tolerability of budesonide-MMX and oral mesalamine in active, mild-to-moderate ulcerative colitis (UC) are unclear. We conducted a network meta-analysis to fill this evidence gap. ...

Article

Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysis

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Lytras, Theodore; Fiorino, Gionata; Peyrin‐Biroulet, Laurent; Danese, Silvio (2018)

Aims Oral systemic corticosteroids have been used to induce remission in patients with active inflammatory bowel disease (IBD) for over 50 years

Article

Comparison between Nageotte and flow cytometric counting of residual leucocytes in freshly prepared leucocyte-reduced red blood cell components

Nikolopoulos, Georgios K.; Kyriakou, Elias; Nearchakos, Nikolaos; Bonovas, Stefanos; Makri, Efstathia; Pantavou, Katerina; Kottaridi, Christine; Gialeraki, Argyri; Douramani, Panagiota; Taichert, Maria; Kapsimali, Violetta; Tsantes, Argirios E. (2018)

Background Flow cytometry (FC) and Nageotte hemocytometry represent the most widely accepted methods for counting residual white blood cells (rWBCs) in leucocyte-reduced (LR) blood components. Our aim was to study the ...

Article

Condom effectiveness in reducing heterosexual HIV transmission: a systematic review and meta-analysis of studies on HIV serodiscordant couples

Giannou, Foteini K.; Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Talias, M.; Benetou, Vasiliki; Kantzanou, Maria; Bonovas, Stefanos; Hatzakis, A. (2016)

Objective: This systematic review and meta-analysis aimed to reassess the effectiveness of condoms in reducing heterosexual transmission of HIV. Methods: Medline, Scopus, and the ISI Web of Science databases were searched ...

Article

Cost-effectiveness of leucoreduction for prevention of febrile non-haemolytic transfusion reactions

Tsantes, Argirio E.; Kyriakou, Elias; Nikolopoulos, Georgios K.; Stylos, D.; Sidhom, M.; Bonovas, Stefanos; Douramani, Panagiota; Kalantzis, Dimitrios; Kokoris, Styliani; Valsami, S.; Stamoulis, K.; Politou, M.; Foudoulaki-Paparizos, Leontini (2014)

Background. The cost-effectiveness of universal leucoreduction of blood components remains unclear. When using leucoreduced red blood cells, the decrease in the rate of febrile non-haemolytic transfusion reactions (FNHTR) ...

Article

Developing the evidence base for cancer chemoprevention: Use of meta-analysis

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)

Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

Article

An ecological study of the determinants of differences in 2009 pandemic influenza mortality rates between countries in Europe

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Lytras, Theodoros; Bonovas, Stefanos (2011)

Background: Pandemic A (H1N1) 2009 mortality rates varied widely from one country to another. Our aim was to identify potential socioeconomic determinants of pandemic mortality and explain between-country variation. ...

Article

Editorial: evidence is growing for protective effects of 5-aminosalicylates against colitis-associated cancer—authors’ reply

Bonovas, Stefanos; Fiorino, Gionata; Lytras, Theodoros; Nikolopoulos, Georgios K.; Peyrin-Biroulet, L.; Danese, Silvio (2017)

Article

Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome

Tsantes, Argirio E.; Kopterides, Petros; Bonovas, Stefanos; Bagos, Pantelis G.; Antonakos, Georgios; Nikolopoulos, Georgios K.; Gialeraki, Argiri; Kapsimali, Violetta; Kyriakou, Elias; Kokoris, Styliani; Dima, Kleanthi; Armaganidis, Apostolos; Tsangaris, I. (2013)

Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ...

Article

The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk

Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos; Kopterides, Petros; Vaiopoulos, G. (2008)

Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma ...