Browsing by Author "Boucher, Y."
Now showing items 1-5 of 5
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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
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Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
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Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure
Chauhan, V.; Boucher, Y.; Ferrone, C.; Roberge, S.; Martin, J.; Stylianopoulos, T.; Bardeesy, N.; DePinho, R.; Padera, T.; Munn, L.; Jain, R. (2014)
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Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies
Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
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Mathematical modeling of herpes simplex virus distribution in solid tumors: Implications for cancer gene therapy
Mok, W.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2009)Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical ...