Browsing by Author "Carty, Michael P."
Now showing items 1-3 of 3
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Article
Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors
Keane, Lee-Ann J.; Mirallai, Styliana I.; Sweeney, Martin; Carty, Michael P.; Zissimou, Georgia A.; Berezin, Andrey A.; Koutentis, Panayiotis A.; Aldabbagh, Fawaz (2018)Cell viability studies for benzo[1,2,4]triazin-7-ones and 1,2,4-benzotriazinyl (Blatter-type) radical precursors are described with comparisons made with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). All of the stable free ...
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Article
Discovery of anti-cancer activity for benzo1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition
Sweeney, Martin; Coyle, Robert; Kavanagh, Paul; Berezin, Andrey A.; Lo Re, Daniele; Zissimou, Georgia A.; Koutentis, Panayiotis Andreas; Carty, Michael P.; Aldabbagh, Fawaz (2016)
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Article
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition
Sweeney, M.; Coyle, R.; Kavanagh, P.; Berezin, Andrey A.; Lo Re, D.; Zissimou, Georgia A.; Koutentis, Panayiotis Andreas; Carty, Michael P.; Aldabbagh, Fawaz (2016)The thioredoxin (Trx)–thioredoxin reductase (TrxR) system plays a key role in maintaining the cellular redox balance with Trx being over-expressed in a number of cancers. Inhibition of TrxR is an important strategy for ...