Browsing by Author "Charalambous, Christina"
Now showing items 1-8 of 8
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Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27Kip1-dependent G1/S cell cycle arrest in conjunction with NF-κB activation
Batsi, Christina; Markopoulou, Soultana; Kontargiris, Evangelos; Charalambous, Christina; Thomas, Christoforos G.; Christoforidis, Savvas; Kanavaros, Panagiotis E.; Constantinou, Andreas I.; Marcu, Kenneth B.; Kolettas, Evangelos (2009)2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain ...
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Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
Charalambous, Christina; Pitta, Chara A.; Constantinou, Andreas I. (2013)Background: Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer ...
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In vitro antioxidant activity and phenolic content of Cedrus brevifolia bark
Cretu, E.; Salminen, J. -P; Karonen, M.; Miron, A.; Charalambous, Christina; Constantinou, Andreas I.; Aprotosoaie, A. C. (2014)A raw extract and four extractive fractions were obtained from Cedrus brevifolia (Cyprus cedar) bark. They were all studied regarding the phenolic content and profile using spectrophotometry and HPLC-DAD-ESI-MS. The ...
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In vitro study on the antioxidant activity of a polyphenol-rich extract from pinus brutia bark and its fractions
Cretu, E.; Karonen, M.; Salminen, J. -P; Mircea, C.; Trifan, A.; Charalambous, Christina; Constantinou, Andreas I.; Miron, A. (2013)A crude hydromethanolic extract from Pinus brutia bark and its fractions (diethyl ether, ethyl acetate, n-butanol, and aqueous fractions) were studied with regard to their phenolic content and antioxidant activities. The ...
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Novel spatiotemporal glycome changes in the murine placenta during placentation based on BS-I lectin binding patterns
Charalambous, Christina; Drakou, Katerina; Nicolaou, Stavros; Georgiades, Pantelis (2013)Although spatiotemporal changes of the glycome (full set of glycans, otherwise known as saccharides or carbohydrates) during placenta formation (placentation) are functionally and clinically important, they are poorly ...
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Novel Spatiotemporal Glycome Changes in the Murine Placenta During Placentation Based on BS‐I Lectin Binding Patterns
Charalambous, Christina; Drakou, Katerina; Nicolaou, Stavros; Georgiades, Pantelis (2013)
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Article
Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance
Pitta, Chara A.; Papageorgis, P.; Charalambous, Christina; Constantinou, Andreas I. (2013)The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen resistance (MCF-7/TAM-R) and this ...
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Vernonia kotschyana roots: Therapeutic potential via antioxidant activity
Vasincu, A.; Paulsen, B. S.; Diallo, D.; Vasincu, I.; Aprotosoaie, A. C.; Bild, V.; Charalambous, Christina; Constantinou, Andreas I.; Miron, A.; Gavrilescu, C. M. (2014)The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, ...