Browsing by Author "Chauhan, V. P."

Now showing items 1-6 of 6

    • Article  

      Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
    • Article  

      Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)
      The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
    • Article  

      Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies 

      Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)
      Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
    • Article  

      Multistage nanoparticle delivery system for deep penetration into tumor tissue 

      Wong, C.; Stylianopoulos, T.; Cui, J.; Martin, J.; Chauhan, V. P.; Jiang, W.; Popovic, Z.; Jain, R. K.; Bawendi, M. G.; Fukumura, D. (2011)
      Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
    • Article  

      Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner 

      Chauhan, V. P.; Stylianopoulos, T.; Martin, J. D.; PopoviÄ, Z.; Chen, O.; Kamoun, W. S.; Bawendi, M. G.; Fukumura, D.; Jain, R. K. (2012)
      The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
    • Conference Object  

      Residual stresses in solid tumors: Implications to tumor growth and drug delivery 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Munn, L. L.; Jain, R. K. (Affiliation: Edwin L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United StatesAffiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusCorrespondence Address: Edwin L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United States, 2012)