Browsing by Author "Das Gupta, T. K."
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Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer
Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...
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Article
Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: Evidence for a potential role as a chemopreventive agent
Salti, G. I.; Kichina, J. V.; Das Gupta, T. K.; Uddin, S.; Bratescu, L.; Pezzuto, J. M.; Mehta, R. G.; Constantinou, Andreas I. (2001)Melanoma transformation progresses in a multistep fashion from precursor lesions such as congenital naevi. Exposure to ultraviolet (UV) light promotes this process. Betulinic acid (BA) was identified by our group as a ...
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Article
Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells
Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells
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A novel use for the comet assay: Detection of topoisomerase II inhibitors
Salti, G. I.; Das Gupta, T. K.; Constantinou, Andreas I. (2000)Background: The simple and quick comet assay can quantitatively detect DNA cleavage in cells. This study aimed to determine whether the comet assay could be used to detect topoisomerase (topo) II inhibitors. Materials and ...
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Article
Targeting colon cancer cells with genistein-17.1A immunoconjugate.
Gentile, M. S.; Vasu, C.; Green, A.; Murillo, G.; Das Gupta, T. K.; Constantinou, Andreas I.; Prabhakar, B. S.; Salti, G. I. (2003)We have shown that genistein, a major component of soy, has anti-colon cancer effects in vitro. These effects are attainable at high concentrations that are difficult to achieve in the serum. The purpose of this study was ...