Browsing by Author "Dietis, Nikolas"
Now showing items 1-20 of 20
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Article
Age-dependent antinociception and behavioral inhibition by morphine
Paul, Alok Kumar; Gueven, Nuri; Dietis, Nikolas (2018)In current clinical practice, morphine is dosed in older patients based on patient-weight, with different calculations for adjustment. However, at present, neither clinical experience nor the literature offers a clear ...
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Article
Antinociceptive effects of the bifunctional opioid UFP-505
Dietis, Nikolas; Niwa, H.; Ruggieri, V.; Filaferro, M.; Novi, C.; Guerrini, R.; Calo, G.; Rowbotham, D. J.; Vitale, G.; Lambert, D. G. (2011)
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Article
Characterization of the bifunctional opioid UFP505
Tose, R.; Dietis, Nikolas; McDonald, J.; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2010)Morphine is a gold standard analgesic acting at μ-opioid receptors (MOP) with analgesia accompanied by side-effects, for example, tolerance. If δ-opioid receptors (DOP) are blocked at the same time that MOP is activated, ...
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Book Chapter
Computational Drug Repurposing for Neurodegenerative Diseases
Savva, Kyriaki; Zachariou, Margarita; Oulas, Anastasis; Minadakis, George; Sokratous, Kleitos; Dietis, Nikolas; Spyrou, George M. (Academic Press, 2019)Currently, most of the neurodegenerative diseases lack effective therapeutic drugs. The present burden of these diseases on society highlights the need to develop novel approaches for their treatment. The detection of novel ...
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Article
Controlling cancer pain: Is morphine the best we can do?
Dietis, Nikolas; Rowbotham, D. J.; Lambert, D. G. (2011)Despite the existence of a family of 3 classical and one non-classical opioid receptor, morphine, acting at the MOP (μ) receptor remains the gold standard for use in cancer pain. The main thrust of opioid development has ...
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Article
Data on prolonged morphine-induced antinociception and behavioral inhibition in older rats
Paul, Alok Kumar; Gueven, Nuri; Dietis, Nikolas (2018)This article contains supportive data related to a research article entitled "Age-dependent antinociception and behavioral inhibition by morphine" (Paul et al., 2018) [1]. Antinociceptive latencies of 8 and 24-week old ...
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Article
Heparin activity-assay of liposomal formulations
Dietis, Nikolas (2006)It is very important for a liposomal formulation that the encapsulated substance will be active upon release from the vesicle. Chemical reactions between the drug and its liposome carrier or the active site of the drug may ...
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Article
In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505
Dietis, Nikolas; Niwa, H.; Tose, R.; McDonald, J.; Ruggieri, V.; Filaferro, M.; Vitale, G.; Micheli, L.; Ghelardini, C.; Salvadori, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2018)Background and Purpose Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reducing side-effects. We have evaluated the mixed μ opioid receptor agonist/ δ opioid receptor antagonist ...
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Article
Liposomal composition and storage temperature affect loading efficiency of heparin
Dietis, Nikolas (2005)Two of the major factors affecting the encapsulation of any drug in liposomes is liposomal composition and storage temperature. However, this project evaluated the influence of the combination of both these factors on ...
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Article
Morphine dosing strategy plays a key role in the generation and duration of the produced antinociceptive tolerance
Paul, A. K.; Gueven, Nuri; Dietis, Nikolas (2017)Antinociceptive tolerance after repetitive administration of morphine severely limits its clinical use. Despite increased mechanistic understanding of morphine tolerance, little is known about the influence of dosing ...
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Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
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Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
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Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
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Article
Opioid receptor subtypes: Fact or artifact?
Dietis, Nikolas; Rowbotham, D. J.; Lambert, D. G. (2011)There is a vast amount of pharmacological evidence favouring the existence of multiple subtypes of opioid receptors. In addition to the primary classification of (mu: MOP), δ (delta: DOP), κ (kappa: KOP) receptors, and the ...
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Article
Opioid receptor-dependent modulation of insulin-release in pancreatic beta-cells.
Paul, A. K.; Guven, Nuri; Dietis, Nikolas (2014)
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Article
Opioids in depression: not quite there yet
Yin, X.; Guven, Nuri; Dietis, Nikolas (2015)
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Article
Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505)
Dietis, Nikolas; McDonald, J.; Molinari, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2012)BackgroundWhile producing good-quality analgesia,-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of δ-opioid (DOP) receptors has been shown to reduce tolerance ...
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Article
Simultaneous targeting of multiple opioid receptors: A strategy to improve side-effect profile
Dietis, Nikolas; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2009)Opioid receptors are currently classified as (mu: mOP), δ (delta: dOP), κ (kappa: kOP) with a fourth related non-classical opioid receptor for nociceptin/orphainin FQ, NOP. Morphine is the current gold standard analgesic ...
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Article
Stress-based animal models of depression: Do we actually know what we are doing?
Yin, X.; Guven, Nuri; Dietis, Nikolas (2016)Depression is one of the leading causes of disability and a significant health-concern worldwide. Much of our current understanding on the pathogenesis of depression and the pharmacology of antidepressant drugs is based ...
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Article
Ways to increase adherence to allergen immunotherapy
Pitsios, Constantinos; Dietis, Nikolas (2019)Adherence to allergen immunotherapy (AIT) is crucial for its efficacy. Subcutaneous AIT requires monthly visits (or more extended in the case of venom immunotherapy), while sublingual AIT is performed with a daily intake ...