Browsing by Author "Georgiou, I."
Now showing items 1-4 of 4
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Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: To target or not to target?
Dova, L.; Pentheroudakis, George; Georgiou, I.; Malamou-Mitsi, Vassiliki D.; Vartholomatos, G.; Fountzilas, George; Kolaitis, N.; Kitsou, E.; Pavlidis, Nicholas (2007)Introduction: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of ...
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Systemic dissemination in cancer of unknown primary is independent of mutational inactivation of the KiSS-1 metastasis-suppressor gene
Dova, L.; Golfinopoulos, Vassilis; Pentheroudakis, George; Georgiou, I.; Pavlidis, Nicholas (2008)Cancer of unknown primary represents a heterogeneous group of malignancies characterised by early systemic dissemination and lack of primary site. KiSS1 is a member of the metastasis-suppressor gene family whose functional ...
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Targeting c-KIT, PDGFR in cancer of unknown primary: A screening study for molecular markers of benefit
Dova, L.; Pentheroudakis, George; Golfinopoulos, Vassilis; Malamou-Mitsi, Vassiliki D.; Georgiou, I.; Vartholomatos, G.; Ntemou, A.; Fountzilas, George; Pavlidis, Nicholas (2008)Aims: In view of available targeted therapies, we investigated the presence of c-kit, PDGFR gene mutations and protein expression in cancer of unknown primary (CUP) in order to study their contribution in pathogenesis, ...
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A twisted kiss: In vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer
Pentheroudakis, George; Kostadima, Lida; Dova, L.; Georgiou, I.; Tzavaras, T.; Vartholomatos, G.; Wirtz, R. M.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2010)KiSS-1 is a metastasis suppressor gene, its inactivation linked to advanced tumor stage and dismal prognosis. We studied its mutational status, transcription and protein expression in human cancer cell lines and patients ...