Browsing by Author "Gkretsi, Vasiliki"
Now showing items 1-10 of 10
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Atomic force microscopy nano-characterization of 3D collagen gels with tunable stiffness
Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)As extracellular matrix (ECM) nano-characteristics play a crucial role in cell behavior, including cancer development and metastasis, several ECM in vitro models have been used in order to study cells behavior under different ...
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Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis
Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's adhesome at cell-ECM adhesion sites and ...
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Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts
Stylianou, Andreas; Gkretsi, Vasiliki; Louca, Maria; Zacharia, Lefteris C.; Stylianopoulos, Triantafyllos (2019)In many solid tumours a desmoplastic reaction takes place, which results in tumour tissue stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as collagen, by stromal cells, mainly ...
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Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion
Louca, Maria; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor due to its invasive phenotype. Ras suppressor 1 (RSU-1) is a cell-extracellular matrix adhesion protein and we recently found that it promotes cell ...
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Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform
Gkretsi, Vasiliki; Kalli, Maria; Efstathiades, Christodoulos; Papageorgis, Panagiotis; Papanikolaou, Vassilios; Zacharia, Lefteris C.; Tsezou, Aspasia; Athanassiou, Evangelos; Stylianopoulos, Triantafyllos (2019)Extracellular matrix (ECM)-adhesion proteins and actin cytoskeleton are pivotal in cancer cell invasion. Ras Suppressor-1 (RSU-1), a cell-ECM adhesion protein that interacts with PINCH-1, thus being connected to Integrin ...
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Editorial: Metastasis: From Cell Adhesion and Beyond
Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)
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Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation
Louca, Maria; Stylianou, Andreas; Minia, Angeliki; Pliaka, Vaia; Alexopoulos, Leonidas G.; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) ...
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Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
Kalli, Maria; Papageorgis, Panagiotis; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
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Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion
Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Background Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including ...
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Tuning the Mechanical Properties of BIEE-Crosslinked Semi-Interpenetrating, Double-Hydrophilic Hydrogels
Papaparaskeva, Georgia; Voutouri, Chrysovalantis; Gkretsi, Vasiliki; Achilleos, Mariliz; Safarik, Ivo; Pospiskova, Kristyna; Stylianopoulos, Triantafyllos; Krasia‐Christoforou, Theodora (2018)Double-hydrophilic, semi-interpenetrating (semi-IPN) hydrogels are synthesized by encapsulating hydrophilic polyvinylpyrrolidone (PVP) linear chains in structure-defined 1,2-bis-(2-iodoethoxy)ethane (BIEE)-crosslinked ...