Browsing by Author "Kamoun, W. S."
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Article
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
Chauhan, V. P.; Stylianopoulos, T.; Martin, J. D.; PopoviÄ, Z.; Chen, O.; Kamoun, W. S.; Bawendi, M. G.; Fukumura, D.; Jain, R. K. (2012)The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
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Article
Scaling rules for diffusive drug delivery in tumor and normal tissues
Baish, J. W.; Stylianopoulos, T.; Lanning, R. M.; Kamoun, W. S.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2011)Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...