Browsing by Author "Karanicolas, R."
Now showing items 1-6 of 6
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Effect of recent thymic emigrants on progression of HIV-1 disease
Hatzakis, Angelos E.; Touloumi, G.; Karanicolas, R.; Karafoulidou, A.; Mandalaki, T.; Anastassopoulou, C. G.; Zhang, L.; Goedert, J. J.; Ho, David D.; Kostrikis, Leontios G. (2000)Background. The concentration of T-cell receptor-rearrangement excision DNA circles (TREC) in peripheral-blood T cells is a marker of recent thymic emigrant αβ T cells. We studied the predictive ability of measurements of ...
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Article
Emergence of Minor Populations of Human Immunodeficiency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions
Metzner, K. J.; Bonhoeffer, S.; Fischer, M.; Karanicolas, R.; Allers, K.; Joos, B.; Weber, R.; Hirschel, B.; Kostrikis, Leontios G.; Günthard, H. F. (2003)The use of structured treatment interruption (STI) in human immunodeficiency virus (HIV)-infected subjects is currently being studied as an alternative therapeutic strategy for HIV-1. The potential risk for selection of ...
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Article
Global distribution of the CCR2-641/CCR5-59653T HIV-1 disease-protective haplotype
Martinson, J. J.; Hong, L.; Karanicolas, R.; Moore, J. P.; Kostrikis, Leontios G. (2000)Objectives: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. The CCR2-641 genetic variant [a G to A substitution resulting in a valine (V) to ...
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Article
Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
Zhang, L.; Lewin, S. R.; Markowitz, M.; Lin, L. -H; Skulsky, E.; Karanicolas, R.; Yuxian, H.; Xia, J.; Tuttleton, S.; Vesanen, M.; Spiegel, H.; Kost, R.; Van Lunzen, J.; Stellbrink, H. -J; Wolinsky, S.; Borkowsky, W.; Palumbo, P.; Kostrikis, Leontios G.; Ho, David D. (1999)The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed α1 circle) ...
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Article
A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants
Deutsch, L.; Kostrikis, Leontios G.; Neumann, A. U.; Thomson, B.; Korber, B. T.; McHardy, P.; Karanicolas, R.; Huang, Y.; Lew, J. F.; McIntosh, K.; Pollack, H.; Borkowsky, W.; Spiegel, H. M. L.; Palumbo, P.; Oleske, J.; Bardeguez, A.; Luzuriaga, K.; Sullivan, J.; Wolinsky, S. M.; Koup, R. A.; Ho, David D.; Moore, J. P. (1999)There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous ...
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Quantitation of human immunodeficiency virus type 1 DNA forms with the second template switch in peripheral blood cells predicts disease progression independently of plasma RNA load
Kostrikis, Leontios G.; Touloumi, G.; Karanicolas, R.; Pantazis, N.; Anastassopoulou, C. G.; Karafoulidou, A.; Goedert, J. J.; Hatzakis, Angelos E. (2002)There are several forms of human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood T cells and lymph nodes in untreated HIV-1-infected individuals and in patients whose plasma HIV-1 RNA levels are suppressed ...