Browsing by Author "Kyriacou, Kyriacos C."

Now showing items 1-20 of 21

    • Article  

      AM-FM texture segmentation in electron microscopic muscle imaging 

      Pattichis, Marios S.; Pattichis, Constantinos S.; Avraam, Maria; Bovik, Alan Conrad; Kyriacou, Kyriacos C. (2000)
      This paper describes the application of an amplitude modulation-frequency modulation (AM-FM) image representation in segmenting electron micrographs of skeletal muscle for the recognition of: 1) normal sarcomere ultrastructural ...
    • Article  

      Amphiphilic Polymer Conetworks Based on Interconnected Hydrophobic Star Block Copolymers: Synthesis and Characterization 

      Kepola, Eleni J.; Kyriacou, Kyriacos C.; Patrickios, Costas S.; Simon, Miriam; Gradzielski, M.; Kushnir, M.; Wesdemiotis, Chrystostomos (2017)
      Herein we report on the preparation and structural characterization of six amphiphilic polymer conetworks (APCN) based on end-linked amphiphilic “core-first” star block copolymers, comprising methyl methacrylate and ...
    • Article  

      Autosomal-dominant medullary cystic kidney disease type 1: Clinical and molecular findings in six large Cypriot familiesAAA 

      Stavrou, Christoforos V.; Koptides, Michael; Tombazos, C.; Psara, E.; Patsias, Charalambos; Zouvani, Ioanna; Kyriacou, Kyriacos C.; Hildebrandt, F.; Christofides, Tasos C.; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2002)
      Background. Autosomal-dominant medullary cystic kidney disease (ADMCKD), a hereditary chronic interstitial nephropathy, recently attracted attention because of the cloning or mapping of certain gene loci, namely NPHP1, ...
    • Article  

      Clinico-pathological correlations in 127 patients in 11 large pedigrees, segregating one of three heterozygous mutations in the COL4A3 COL4A4 genes associated with familial haematuria and significant late progression to proteinuria and chronic kidney disease from focal segmental glomerulosclerosis 

      Pierides, Alkis M.; Voskarides, Konstantinos; Athanasiou, Yiannis; Ioannou, Kyriakos; Damianou, Loukas; Arsali, Maria; Zavros, Michalis; Pierides, M.; Vargemezis, V.; Patsias, Charalambos; Zouvani, Ioanna; Elia, Avraam; Kyriacou, Kyriacos C.; Constantinou-Deltas, Constantinos D. (2009)
      Background. Heterozygous mutations in the COL4A3 COL4A4 genes are currently thought to be responsible for familial benign microscopic haematuria and maintenance of normal long-term kidney function.Methods. We report on 11 ...
    • Article  

      COL4A3/COL4A4 mutations producing focal segmental glomerulosclerosis and renal failure in thin basement membrane nephropathy 

      Voskarides, Konstantinos; Damianou, Loukas; Neocleous, Vassos; Zouvani, Ioanna; Christodoulidou, Stalo; Hadjiconstantinou, Valsamakis E.; Ioannou, Kyriakos; Athanasiou, Yiannis; Patsias, Charalambos; Alexopoulos, Efstathios; Pierides, Alkis M.; Kyriacou, Kyriacos C.; Constantinou-Deltas, Constantinos D. (2007)
      Mutations in the COL4A3/COL4A4 genes of type IV collagen have been found in ∼40% of cases of thin basement membrane nephropathy, which is characterized by microscopic hematuria and is classically thought to cause proteinuria ...
    • Article  

      Computer-aided classification of breast cancer nuclei 

      Schnorrenberg, F.; Pattichis, Constantinos S.; Schizas, Christos N.; Kyriacou, Kyriacos C.; Vassiliou, M. (1996)
      Breast cancer is the most common malignancy affecting the female population in industrialized countries. Prognostic factors, such as steroid receptors visualized in biopsy slides, provide critical information to oncologists ...
    • Article  

      Computer-aided detection of breast cancer nuclei 

      Schnorrenberg, F.; Pattichis, Constantinos S.; Kyriacou, Kyriacos C.; Schizas, Christos N. (1997)
      A computer-aided detection system for tissue cell nuclei in histological sections is introduced and validated as part of the Biopsy Analysis Support System (BASS). Cell nuclei are selectively stained with monoclonal ...
    • Article  

      Content-based retrieval of breast cancer biopsy slides 

      Schnorrenberg, F.; Pattichis, Constantinos S.; Schizas, Christos N.; Kyriacou, Kyriacos C. (2000)
      The Biopsy Analysis Support System (BASS), previously used for image analysis of immunohistochemically stained sections of breast carcinoma, has been extended to include indexing and content-based retrieval of biopsy slide ...
    • Conference Object  

      Detection of cell nuclei in breast biopsies using receptive fields 

      Schnorrenberg, F.; Pattichis, Constantinos S.; Kyriacou, Kyriacos C.; Schizas, Christos N. (IEEE, 1994)
      A biopsy analysis support system, called BASS, is introduced. The system uses an unsupervised object detection loop involving center-surround receptive fields, and a nonlinearity to mark the location of cell nuclei in an ...
    • Conference Object  

      The effects of applying cell-suppression and perturbation to aggregated genetic data 

      Antoniades, Athos; Keane, J.; Aristodimou, Aristos; Philipou, Christa; Constantinou, Andreas I.; Georgousopoulos, Christos; Tozzi, Federica; Kyriacou, Kyriacos C.; Hadjisavvas, Andreas; Loizidou, Maria A.; Demetriou, Christiana A.; Pattichis, Constantinos S. (2012)
      The key test for confidence in any association discovered within the medical domain is replication testing. That is, the ability of the association to be detected in independent populations. At the same time, in order to ...
    • Article  

      Familial C3 Glomerulopathy Associated with CFHR5 Mutations: Clinical Characteristics of 91 Patients in 16 Pedigrees 

      Athanasiou, Yiannis; Voskarides, Konstantinos; Gale, D. P.; Damianou, Loukas; Patsias, Charalambos; Zavros, Michalis; Maxwell, P. H.; Cook, H. T.; Demosthenous, Panayiota; Hadjisavvas, Andreas; Kyriacou, Kyriacos C.; Zouvani, Ioanna; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2011)
      Background and objectives Complement factor H and related proteins (CFHR) are key regulators of the alternative complement pathway, where loss of function mutations lead to a glomerulopathy with isolated mesangial C3 ...
    • Article  

      Formation mechanism of nanotubes comprising layers of PbS nanoparticles in polymer-surfactant solutions 

      Orphanou, M.; Leontidis, Epameinondas; Kyprianidou-Leodidou, Tasoula; Caseri, Walter; Krumeich, F.; Kyriacou, Kyriacos C. (2006)
      The crystallization of PbS in aqueous solutions containing the surfactant sodium dodecyl sulfate (SDS) and hydrophilic polymers resulted in a novel type of metastable nanotubes, the walls of which consist of layers of ...
    • Article  

      From beads-on-a-string to colloidal aggregation: novel crystallization phenomena in the PEO-SDS system 

      Leontidis, Epameinondas; Kyprianidou-Leodidou, Tasoula; Caseri, Walter; Kyriacou, Kyriacos C. (1999)
      The anionic surfactant sodium dodecyl sulfate (SDS) interacts strongly with poly(ethylene oxide) (PEO) in aqueous solution, forming micellar aggregates attached to the polymer chains above the so-called critical association ...
    • Article  

      From colloidal aggregates to layered nanosized structures in polymer-surfactant systems. 1. Basic phenomena 

      Leontidis, Epameinondas; Kyprianidou-Leodidou, Tasoula; Caseri, Walter; Robyr, P.; Krumeich, F.; Kyriacou, Kyriacos C. (2001)
      In this work, we examine the rich crystallization behavior that occurs in PbII/S-II/poly(ethylene oxide) (PEO)/sodium dodecyl sulfate (SDS) systems, in which the anionic surfactant interacts strongly with the polymer ...
    • Article  

      Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis 

      Gale, D. P.; De Jorge, E. G.; Cook, H. T.; Martinez-Barricarte, R.; Hadjisavvas, Andreas; McLean, A. G.; Pusey, C. D.; Pierides, Alkis M.; Kyriacou, Kyriacos C.; Athanasiou, Yiannis; Voskarides, Konstantinos; Constantinou-Deltas, Constantinos D.; Palmer, A.; De Cordoba, S. R.; Maxwell, P. H.; Pickering, M. C.; Frémeaux-Bacchi, V. (2010)
      Summary Background Complement is a key component of the innate immune system, and variation in genes that regulate its activation is associated with renal and other disease. We aimed to establish the genetic basis for a ...
    • Article  

      Improved detection of breast cancer nuclei using modular neural networks 

      Schnorrenberg, F.; Tsapatsoulis, Nicolas; Pattichis, Constantinos S.; Schizas, Christos N.; Kollias, S.; Vassiliou, M.; Adamou, Adamos K.; Kyriacou, Kyriacos C. (2000)
      A modular neural network-based approach to detect and classify breast cancer nuclei stained for steroid receptors in hispathological sections is evaluated. The system named biopsy analysis support system (BASS) is designed ...
    • Article  

      Medullary cystic kidney disease with hyperuricemia and gout in a large Cypriot family: No allelism with nephronophthisis type 1 

      Stavrou, Christoforos V.; Pierides, Alkis M.; Zouvani, Ioanna; Kyriacou, Kyriacos C.; Antignac, C.; Neophytou, Pavlos; Christodoulou, Kyproula; Constantinou-Deltas, Constantinos D. (1998)
      We describe a large Cypriot family with an interstitial type of nephropathy, inherited as an autosomal dominant trait that led to end stage renal failure between 51 to 78 years of age (mean 62.2 years). Twenty-three people ...
    • Article  

      A Simplified Method for Measuring the Thickness of Glomerular Basement Membranes 

      Marquez, B.; Zouvani, Ioanna; Karagrigoriou, Alex; Anastasiades, E.; Pierides, Alkis M.; Kyriacou, Kyriacos C. (2003)
      Measurement of the thickness of glomerular basement membranes is required for the diagnosis of thin membrane nephropathy. Over the years various morphometric methods have been used but some are laborious so there is a need ...
    • Article  

      Statistical modelling and prognostic analysis in primary breast carcinoma 

      Vonta, Filia; Karagrigoriou, Alex; Adamou, Adamos K.; Zouvani, Ioanna; Kyriacou, Kyriacos C. (2000)
      This work reports, for the first time, the results of the first retrospective study on breast cancer in Cyprus. The study which is based on 197 women with primary breast cancer who have undergone modified radical mastectomy ...
    • Article  

      Study of copper sulfide crystallization in PEO-SDS solutions 

      Orphanou, M.; Leontidis, Epameinondas; Kyprianidou-Leodidou, Tasoula; Koutsoukos, Petros George; Kyriacou, Kyriacos C. (2004)
      The crystallization of copper sulfide in aqueous supersaturated solutions in the presence of the polymer poly(ethylene oxide), PEO, and the surfactant sodium dodecyl sulfate, SDS, was investigated. In these systems, copper ...