Browsing by Author "Lambrou, Alexandra"
Now showing items 1-7 of 7
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Assessment of stroke risk based on morphological ultrasound image analysis with conformal prediction
Lambrou, Alexandra; Papadopoulos, Harris; Kyriacou, Efthyvoulos C.; Pattichis, Constantinos S.; Pattichis, Marios S.; Gammerman, A.; Nicolaïdes, Andrew N. (2010)Non-invasive ultrasound imaging of carotid plaques allows for the development of plaque image analysis in order to assess the risk of stroke. In our work, we provide reliable confidence measures for the assessment of stroke ...
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Article
Coupling of helix E-F motion with the O-nitrito and 2-nitrovinyl coordination in myoglobin
Ioannou, Androulla; Lambrou, Alexandra; Daskalakis, Vangelis; Pinakoulaki, Eftychia (2017)Myoglobin (Mb) is known to react slowly with nitirite to form the green pigment by NO2 − cordination to the heme Fe in the O-binding nitrito (O1[sbnd]N[dbnd]O2) mode and to the heme 2-vinyl position. Nitrite is a powerful ...
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Article
Evaluation of the risk of stroke with confidence predictions based on ultrasound carotid image analysis
Lambrou, Alexandra; Papadopoulos, Harris; Kyriacou, Efthyvoulos C.; Pattichis, Constantinos S.; Pattichis, Marios S.; Gammerman, A.; Nicolaïdes, Andrew N. (2012)Conformal Predictors (CPs) are Machine Learning algorithms that can provide reliable confidence measures to their predictions. In this work, we make use of the Conformal Prediction framework for the assessment of stroke ...
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Article
Nitrite coordination in myoglobin
Ioannou, Androulla; Lambrou, Alexandra; Daskalakis, Vangelis; Pinakoulaki, Eftychia (2017)The coordination of nitrite in myoglobin (Mb) has been characterized by resonance Raman spectroscopy and the frequencies of the nitrite bound to the heme Fe as well to the 2-vinyl have been computed by density functional ...
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Resonance Raman detection of the myoglobin nitrito heme Fe-O-N=O/2-nitrovinyl species: Implications for helix E-helix F interactions
Lambrou, Alexandra; Pinakoulaki, Eftychia (2015)The description of biological activity in heme proteins responsible for activating small molecules requires identification of ligand movement into the metal and non-metal binding sites. Mechanisms of nitrite reductase ...
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Spin Crossover in Nitrito-Myoglobin as Revealed by Resonance Raman Spectroscopy
Lambrou, Alexandra; Ioannou, Androulla; Pinakoulaki, Eftychia (2016)The myoglobin (Mb) heme Fe-O-N=O and heme Fe-O-N=O/2-nitrovinyl species have been characterized by resonance Raman spectroscopy. In the heme Fe-O-N=O species, the bound nitrite ligand is removed by solvent exchange, thus ...
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Article
Spin Crossover in Nitrito‐Myoglobin as Revealed by Resonance Raman Spectroscopy
Lambrou, Alexandra; Ioannou, Androulla; Pinakoulaki, Eftychia (2016)