Browsing by Author "Lombardo,Michael V."
Now showing items 1-20 of 43
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Atypical neural self-representation in autism
Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Suckling,John; Baron-Cohen,Simon (2010)The 'self' is a complex multidimensional construct deeply embedded and in many ways defined by our relations with the social world. Individuals with autism are impaired in both self-referential and other-referential social ...
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Autism
Lai,Meng-Chuan; Lombardo,Michael V.; Baron-Cohen,Simon (2014)Autism is a set of heterogeneous neurodevelopmental conditions, characterised by early-onset difficulties in social communication and unusually restricted, repetitive behaviour and interests. The worldwide population ...
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A behavioral comparison of male and female adults with high functioning autism spectrum conditions
Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Wheelwright,Sally J.; Sadek,Susan A.; Chakrabarti,B.; Baron-Cohen,Simon (2011)Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the ...
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Biological sex affects the neurobiology of autism
Lai,Meng-Chuan; Lombardo,Michael V.; Suckling,John; Ruigrok,Amber N. V.; Chakrabarti,B.; Ecker,C.; Deoni,Sean C. L.; Craig, Michael C.; Murphy,Declan G. M.; Bullmore,Edward T.; Baron-Cohen,Simon (2013)In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females ...
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Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: A multicenter magnetic resonance imaging study
Ecker,C.; Suckling,John; Deoni,Sean C. L.; Lombardo,Michael V.; Bullmore,Edward T.; Baron-Cohen,Simon; Catani, Marco; Jezzard, Peter; Barnes, Anna; Bailey, Anthony J.; Williams,Steven C. R.; Murphy,Declan G. M. (2012)Context: There is consensus that autism spectrum disorder (ASD) is accompanied by differences in neuroanatomy. However, the neural substrates of ASD during adulthood, as well as how these relate to behavioral variation, ...
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Brain and behavioral correlates of action semantic deficits in autism
Moseley, Rachel L.; Mohr, Bettina; Lombardo,Michael V.; Baron-Cohen,Simon; Hauk, Olaf; Pulvermueller, Friedemann (2013)Action-perception circuits containing neurons in the motor system have been proposed as the building blocks of higher cognition; accordingly, motor dysfunction should entail cognitive deficits. Autism spectrum conditions ...
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Brain routes for reading in adults with and without autism: EMEG evidence
Moseley, Rachel L.; Pulvermueller, Friedemann; Mohr, Bettina; Lombardo,Michael V.; Baron-Cohen,Simon; Shtyrov, Yury (2014)Reading utilises at least two neural pathways. The temporal lexical route visually maps whole words to their lexical entries, whilst the nonlexical route decodes words phonologically via parietal cortex. Readers typically ...
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Brain surface anatomy in adults with autism: The relationship between surface area, cortical thickness, and autistic symptoms
Ecker,C.; Ginestet, Cedric E.; Feng, Yue; Johnston,Patrick; Lombardo,Michael V.; Lai,Meng-Chuan; Suckling,John; Palaniyappan, Lena; Daly,Eileen M.; Murphy,Clodagh M.; Williams,Steven C. R.; Bullmore,Edward T.; Baron-Cohen,Simon; Brammer, Michael; Murphy,Declan G. M. (2013)Context: Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct parameters, cortical thickness (CT) and ...
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Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers
Pramparo, Tiziano; Lombardo,Michael V.; Campbell, Kathleen; Barnes, Cynthia Carter; Marinero, S.; Solso, S.; Young, Julia; Mayo, Maisi; Dale, Anders; Ahrens-Barbeau, Clelia; Murray, Sarah S.; Lopez, Linda; Lewis, Nathan E.; Pierce, Karen; Courchesne, Eric (2015)Genetic mechanisms underlying abnormal early neural development in toddlers with Autism Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene expression measurement during critical periods ...
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Cognition in Males and Females with Autism: Similarities and Differences
Lai,Meng-Chuan; Lombardo,Michael V.; Ruigrok,Amber N. V.; Chakrabarti,B.; Wheelwright,Sally J.; Auyeung, Bonnie; Allison, Carrie; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Williams,Steven C. R.; Baron-Cohen,Simon (2012)The male bias in autism spectrum conditions (ASC) has led to females with ASC being under-researched. This lack of attention to females could hide variability due to sex that may explain some of the heterogeneity within ...
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Different functional neural substrates for good and poor language outcome in autism
Lombardo,Michael V.; Pierce, Karen; Eyler, Lisa T.; CarterBarnes, C.; Ahrens-Barbeau, Clelia; Solso, S.; Campbell, Kathleen; Courchesne, Eric (2015)Autism (ASD) is vastly heterogeneous, particularly in early language development. While ASD language trajectories in the first years of life are highly unstable, by early childhood these trajectories stabilize and arepredictive ...
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The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation
Charman, T.; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, C.; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen,Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Y.; Chakrabarti,B.; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, G.; Durston, Sarah; Ecker,C.; Faulkner, J.; Frouin, Vincent; Garces, Pilar; Ham, Lindsay M.; Hayward, Hannah; Hipp, Joerg; Holt, R. J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai,Meng-Chuan; D'Ardhuy, X. L.; Lombardo,Michael V.; Lythgoe, David J.; Mandl, Rene; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan J.; Persico, Antonio M.; Ruggeri, B.; Ruigrok,Amber N. V.; Sabet, Jessica; Sacco, Roberto; Caceres, Antonia San Jose; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams,Steven C. R.; Zwiers, Marcel P.; Spooren, Will; Murphy,Declan G. M.; Buitelaar, Jan K. (2017)Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes ...
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Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
Lombardo,Michael V.; Ashwin, Emma; Auyeung, Bonnie; Chakrabarti,B.; Lai,Meng-Chuan; Taylor, Kevin; Hackett, Gerald; Bullmore,Edward T.; Baron-Cohen,Simon (2012)Background: Sex differences are present in many neuropsychiatric conditions that affect emotion and approach-avoidance behavior. One potential mechanism underlying such observations is testosterone in early development. ...
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Fetal testosterone influences sexually dimorphic gray matter in the human brain
Lombardo,Michael V.; Ashwin, Emma; Auyeung, Bonnie; Chakrabarti,B.; Taylor, Kevin; Hackett, Gerald; Bullmore,Edward T.; Baron-Cohen,Simon (2012)In nonhuman species, testosterone is known to have permanent organizing effects early in life that predict later expression of sex differences in brain and behavior. However, in humans, it is still unknown whether such ...
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Frontal networks in adults with autism spectrum disorder
Catani, Marco; Dell’Acqua, Flavio; Budisavljevic, Sanja; Howells, Henrietta; Schotten, Thiebaut De; Froudist-Walsh, Sean; D'Anna, Lucio; Thompson, A.; Sandrone, Stefano; Bullmore,Edward T.; Suckling,John; Baron-Cohen,Simon; Lombardo,Michael V.; Wheelwright,Sally J.; Chakrabarti,B.; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Leemans, Alexander; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2016)It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum ...
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General and specific effects of early-life psychosocial adversities on adolescent grey matter volume
Walsh, Nicholas D.; Dalgleish, Tim; Lombardo,Michael V.; Dunn, Valerie J.; Van Harmelen, Anne-Laura; Ban, Maria; Goodyer, Ian M. (2014)Exposure to childhood adversities (CA) is associated with subsequent alterations in regional brain grey matter volume (GMV). Prior studies have focused mainly on severe neglect and maltreatment. The aim of this study was ...
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Hierarchical cortical transcriptome disorganization in autism
Lombardo,Michael V.; Courchesne, Eric; Lewis, Nathan E.; Pramparo, Tiziano (2017)Background: Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell ...
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Identification and validation of biomarkers for autism spectrum disorders
Loth, Eva; Spooren, Will; Ham, Lindsay M.; Isaac, Maria B.; Auriche-Benichou, Caroline; Banaschewski, Tobias; Baron-Cohen,Simon; Broich, Karl; Boelte, Sven; Bourgeron, Thomas; Charman, Tony; Collier, David; de Andres-Trelles, Fernando; Durston, Sarah; Ecker, Christine; Elferink, Andre; Haberkamp, Marion; Hemmings, Robert; Johnson, Mark H.; Jones, Emily J. H.; Khwaja, Omar S.; Lenton, Sabine; Mason, Luke; Mantua, Valentina; Meyer-Lindenberg, Andreas; Lombardo,Michael V.; O'Dwyer, Laurence; Okamoto, Koichi; Pandina, Gahan J.; Pani, Luca; Persico, Antonio M.; Simonoff, Emily; Tauscher-Wisniewski, Sitra; Llinares-Garcia, Jordi; Vamvakas, Spiros; Williams,Steven C. R.; Buitelaar, Jan K.; Murphy,Declan G. M. (2016)Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders, but effective medical treatments for the core symptoms of the disorder are still lacking. According to the Diagnostic and Statistical ...
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Imaging sex/gender and autism in the brain: Etiological implications
Lai,Meng-Chuan; Lerch, Jason P.; Floris, Dorothea L.; Ruigrok,Amber N. V.; Pohl, A.; Lombardo,Michael V.; Baron-Cohen,Simon (2017)The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform ...
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Impaired Communication Between the Motor and Somatosensory Homunculus Is Associated With Poor Manual Dexterity in Autism Spectrum Disorder
Thompson, A.; Murphy,Clodagh M.; Dell’Acqua, Flavio; Ecker,C.; McAlonan, Grainne; Howells, Henrietta; Baron-Cohen,Simon; Lai,Meng-Chuan; Lombardo,Michael V. (2017)Background Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are ...