• Article  

      Abnormal functional activation and maturation of fronto-striato-temporal and cerebellar regions during sustained attention in autism spectrum disorder 

      Christakou, A.; Giampietro, V.; Brammer, Michael; Smith, A. B.; Robertson, D. M.; Rubia, K.; Bailey, Anthony J.; Baron-Cohen, Simon; Bolton, P. F.; Bullmore, Edward T.; Carrington, S.; Chakrabarti, B.; Daly, Eileen M.; Deoni, Sean C. L.; Ecker, C.; Happé, Francesca; Henty, Julian; Jezzard, Peter; Johnston, Patrick; Jones, D. K.; Lombardo, Michael V.; Madden, A.; Mullins, D.; Murphy, Declan G. M.; Pasco, Greg; Sadek, Susan A.; Spain, D.; Steward, R.; Suckling, John; Wheelwright, Sally J.; Williams, Steven C. R. (2014)
      Objective: Sustained attention problems are common in people with autism spectrum disorder (ASD) and may have significant implications for the diagnosis and management of ASD and associated comorbidities. Furthermore, ASD ...
    • Article  

      Alexithymia in children with and without autism spectrum disorders 

      Griffin, Cait; Lombardo, Michael V.; Auyeung, Bonnie (2016)
      Alexithymia refers to pronounced difficulty in identifying and describing one's own emotions and is associated with an externally oriented focus of thinking. Alexithymia is known to be much more common in adults with autism ...
    • Article  

      Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project 

      Oldehinkel, Marianne; Mennes, Maarten; Marquand, Andre; Charman, Tony; Tillmann, Julian; Ecker, Christine; Dell'Acqua, Flavio; Brandeis, Daniel; Banaschewski, Tobias; Baumeister, Sarah; Moessnang, Carolin; Baron-Cohen, Simon; Holt, Rosemary; Bölte, Sven; Durston, Sarah; Kundu, Prantik; Lombardo, Michael V.; Spooren, Will; Loth, Eva; Murphy, Declan G. M.; Beckmann, Christian F.; Buitelaar, Jan K.; EU-AIMS LEAP group (2019)
      BACKGROUND: Resting-state functional magnetic resonance imaging-based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered ...
    • Article  

      Aminopropyl-modified mesoporous silica SBA-15 as recovery agents of Cu(II)-sulfate solutions: Adsorption efficiency, functional stability and reusability aspects 

      Lombardo, Michael V.; Videla, M.; Calvo, A.; Requejo, F. G.; Soler-Illia, G. J. A. A. (2012)
      Hybrid mesoporous materials are potentially useful for metal ion scavenging and retrieval because of their high surface areas, controlled accessibility and tailored functionalization. Some aspects that are linked to the ...
    • Article  

      The amygdala in autism: Not adapting to faces? 

      Lombardo, Michael V.; Chakrabarti, B.; Baron-Cohen, Simon (2009)
    • Article  

      Are power calculations useful? A multicentre neuroimaging study 

      Suckling, John; Henty, Julian; Ecker, C.; Deoni, Sean C. L.; Lombardo, Michael V.; Baron-Cohen, Simon; Jezzard, Peter; Barnes, Anna; Chakrabarti, B.; Ooi, Cinly; Lai, Meng-Chuan; Williams, Steven C. R.; Murphy, Declan G. M.; Bullmore, Edward T. (2014)
      There are now many reports of imaging experiments with small cohorts of typical participants that precede large-scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration ...
    • Article  

      The ASD Living Biology: from cell proliferation to clinical phenotype 

      Courchesne, Eric; Pramparo, Tiziano; Gazestani, Vahid H.; Lombardo, Michael V.; Pierce, Karen; Lewis, Nathan E. (2019)
      Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, ...
    • Article  

      Association between the probability of autism spectrum disorder and normative sex-related phenotypic diversity in brain structure 

      Ecker, C.; Andrews, Derek Sayre; Gudbrandsen, Christina M.; Marquand, Andre F.; Ginestet, Cedric E.; Daly, Eileen M.; Murphy, Clodagh M.; Lai, Meng-Chuan; Lombardo, Michael V.; Ruigrok, Amber N. V.; Bullmore, Edward T.; Suckling, John; Williams, Steven C. R.; Baron-Cohen, Simon; Craig, Michael C.; Murphy, Declan G. M. (2017)
      IMPORTANCE Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained by sex differences in clinical ...
    • Article  

      Autism attenuates sex differences in brain structure: A combined voxel-based morphometry and diffusion tensor imaging study 

      Beacher, Felix D. C. C.; Minati, L.; Baron-Cohen, Simon; Lombardo, Michael V.; Lai, Meng-Chuan; Gray, Marcus A.; Harrison, Neil A.; Critchley, Hugo D. (2012)
      BACKGROUND AND PURPOSE: It has been proposed that autism spectrums condition may represent a form of extreme male brain (EMB), a notion supported by psychometric, behavioral, and endocrine evidence. Yet, limited data are ...
    • Article  

      Big data approaches to decomposing heterogeneity across the autism spectrum 

      Lombardo, Michael V.; Lai, Meng-Chuan; Baron-Cohen, Simon (2019)
      Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to maximize clinical consensus, it also masks a wide degree of heterogeneity between and within individuals at multiple levels of analysis. ...
    • Article  

      Covariance-based subdivision of the human striatum using T1-weighted MRI 

      Cohen, Michael X.; Lombardo, Michael V.; Blumenfeld, R. S. (2008)
      The striatum plays a key role in many cognitive and emotional processes, and displays an intricate pattern of connectivity with cortical and subcortical structures. Invasive tracing work in rats and non-human primates ...
    • Article  

      Decreased centrality of cortical volume covariance networks in autism spectrum disorders 

      Balardin, J. B.; Comfort, W. E.; Daly, Eileen M.; Murphy, Clodagh M.; Andrews, Derek Sayre; Murphy, Declan G. M.; Ecker, C.; Sato, J. R.; Bailey, Anthony J.; Baron-Cohen, Simon; Bolton, P. F.; Bullmore, Edward T.; Carrington, S.; Catani, Marco; Chakrabarti, B.; Craig, Michael C.; Daly, Eileen M.; Deoni, Sean C. L.; Happé, Francesca; Henty, Julian; Jezzard, Peter; Johnston, Patrick; Jones, D. K.; Lai, Meng-Chuan; Lombardo, Michael V.; Madden, A.; Mullins, D.; Murphy, Clodagh M.; Murphy, Declan G. M.; Pasco, Greg; Ruigrok, Amber N. V.; Sadek, Susan A.; Spain, D.; Stewart, R.; Suckling, John; Wheelwright, Sally J.; Williams, Steven C. R.; Wilson, C. E.; MRC AIMS Consortium (2015)
      Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by atypical structural and functional brain connectivity. Complex network analysis has been mainly used to describe altered ...
    • Article  

      The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder 

      Mann, Caroline; Bletsch, Anke; Andrews, Derek; Daly, Eileen; Murphy, Clodagh; Murphy, Declan; Ecker, Christine; MRC AIMS Consortium; Lombardo, Michael V. (2018)
      Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging study in vivo ...
    • Article  

      Elevated fetal steroidogenic activity in autism 

      Baron-Cohen, Simon; Auyeung, Bonnie; Nørgaard-Pedersen, B.; Hougaard, D. M.; Abdallah, M. W.; Melgaard, L.; Cohen, A. S.; Chakrabarti, B.; Ruta, L.; Lombardo, Michael V. (2015)
      Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor. Utilizing the Danish Historic Birth ...
    • Article  

      In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder 

      Andrews, Derek Sayre; Avino, Thomas A.; Gudbrandsen, Maria; Daly, Eileen M.; Marquand, Andre F.; Murphy, Clodagh M.; Lai, Meng-Chuan; Lombardo, Michael V.; Ruigrok, Amber N. V.; Williams, Steven C. R.; Bullmore, Edward T.; Suckling, John; Baron-Cohen, Simon; Craig, Michael C.; Murphy, Declan G. M.; Ecker, Christine (2017)
      Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that ...
    • Article  

      Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women 

      Bethlehem, R. A. I.; Lombardo, Michael V.; Lai, Meng-Chuan; Auyeung, Bonnie; Crockford, S. K.; Deakin, J. B.; Soubramanian, S.; Sule, A.; Kundu, Prantik; Voon, Valerie; Baron-Cohen, Simon (2017)
      Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate ...
    • Article  

      Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes 

      Lombardo, Michael V.; Pramparo, Tiziano; Gazestani, Vahid; Warrier, Varun; Bethlehem, Richard A. I.; Carter Barnes, Cynthia; Lopez, Linda; Lewis, Nathan E.; Eyler, Lisa; Pierce, Karen; Courchesne, Eric (2018)
      Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple ...
    • Article  

      A Machine Learning Approach to Reveal the NeuroPhenotypes of Autisms 

      Górriz, Juan M.; Ramírez, Javier; Segovia, F.; Martínez, Francisco J.; Lai, Meng-Chuan; Lombardo, Michael V.; Baron-Cohen, Simon; MRC AIMS Consortium; Suckling, John (2019)
      Although much research has been undertaken, the spatial patterns, developmental course, and sexual dimorphism of brain structure associated with autism remains enigmatic. One of the difficulties in investigating differences ...
    • Article  

      Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder 

      Lombardo, Michael V.; Moon, H. M.; Su, J.; Palmer, T. D.; Courchesne, E.; Pramparo, T. (2018)
      Maternal immune activation (MIA) via infection during pregnancy is known to increase risk for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene expression in ways that may explain ...
    • Article  

      A meta-analysis of sex differences in human brain structure 

      Ruigrok, Amber N. V.; Salimi-Khorshidi, G.; Lai, Meng-Chuan; Baron-Cohen, Simon; Lombardo, Michael V.; Tait, Roger J.; Suckling, John (2014)
      The prevalence, age of onset, and symptomatology of many neuropsychiatric conditions differ between males and females. To understand the causes and consequences of sex differences it is important to establish where they ...