Browsing by Author "Mehta, R. G."
Now showing items 1-12 of 12
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Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: Evidence for a potential role as a chemopreventive agent
Salti, G. I.; Kichina, J. V.; Das Gupta, T. K.; Uddin, S.; Bratescu, L.; Pezzuto, J. M.; Mehta, R. G.; Constantinou, Andreas I. (2001)Melanoma transformation progresses in a multistep fashion from precursor lesions such as congenital naevi. Exposure to ultraviolet (UV) light promotes this process. Betulinic acid (BA) was identified by our group as a ...
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Article
Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Thomas, C. F.; Hawthorne, M.; You, M.; Gerhäuser, C.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1995)Brassinin [3-(S-methyldithiocarbamoyl aminomethyl indole], a phytoalexin first identified as a constituent of cabbage, was synthesized and evaluated for cancer chemopreventive activity. Dose-dependent inhibition of ...
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Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues
Mehta, R. G.; Mehta, R. R.; Constantinou, Andreas I.; Moon, R. C. (1995)Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...
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Article
Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice
Murillo, G.; Choi, J. K.; Pan, O.; Constantinou, Andreas I.; Mehta, R. G. (2004)Background: Epidemiological studies have reported a low incidence of colon cancer in countries with high legume consumption. Moreover, experimental studies have found that legumes, such as soybeans and pinto beans, have ...
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Erratum: Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase (Nature Medicine 1, 260-266, (1995))
Gerhauser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)
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Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones
Constantinou, Andreas I.; Mehta, R. G.; Vaughan, A. (1996)Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...
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LiSIs: An online scientific workflow system for virtual screening
Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
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LiSIs: An online scientific workflow system for virtual screeningAAA
Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
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Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1α-hydroxyvitamin D5
Mehta, R. G.; Moriarty, R. M.; Mehta, R. R.; Penmasta, R.; Lazzaro, G.; Constantinou, Andreas I.; Guo, L. (1997)Background: The form of vitamin D (vitamin D3) in fortified milk and the provitamin D produced by the body undergo metabolic activation to a biologically active form, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. This compound ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase
Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Mehta, R. G.; Mar, W.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis
Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Hawthorne, M.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1994)Brassinin, a pkytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective ...