Browsing by Author "Mehta, R. R."
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Article
Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues
Mehta, R. G.; Mehta, R. R.; Constantinou, Andreas I.; Moon, R. C. (1995)Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...
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Article
Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells
Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells
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Article
Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...
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Article
Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function
Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...
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Article
Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1α-hydroxyvitamin D5
Mehta, R. G.; Moriarty, R. M.; Mehta, R. R.; Penmasta, R.; Lazzaro, G.; Constantinou, Andreas I.; Guo, L. (1997)Background: The form of vitamin D (vitamin D3) in fortified milk and the provitamin D produced by the body undergo metabolic activation to a biologically active form, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. This compound ...