Browsing by Author "Mpekris, F."
Now showing items 1-15 of 15
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Alignment of electrospun polymer fibers using a concave collector
Savva, I.; Evaggelou, E.; Papaparaskeva, G.; Leontiou, T.; Stylianopoulos, T.; Mpekris, F.; Stylianou, K.; Krasia-Christoforou, T. (2015)During recent years, electrospinning has become a powerful technique for the cost-effective production of fibrous materials with diameters ranging from a few nanometers up to a few micrometers. In a conventional electrospinning ...
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Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse
Stylianopoulos, T.; Martin, J. D.; Snuderl, M.; Mpekris, F.; Jain, S. R.; Jain, R. K. (2013)The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...
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Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal
Papaphilippou, P.; Vyrides, I.; Mpekris, F.; Stylianopoulos, T.; Papatryfonos, C. A.; Theocharis, C. R.; Krasia-Christoforou, T. (2015)Electrospun microfibrous membranes comprised of poly(methyl methacrylate)-poly((2-diethylamino)ethyl methacrylate) random copolymers (PMMA-co-PDEAEMA) of various chemical compositions blended together with a commercially ...
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Magnetoresponsive polymer networks as adsorbents for the removal of U(VI) ions from aqueous media
Ilia, R.; Liatsou, I.; Savva, I.; Vasile, E.; Vekas, L.; Marinica, O.; Mpekris, F.; Pashalidis, I.; Krasia-Christoforou, T. (2017)Magnetoresponsive, methacrylate-based 3D polymer networks containing hydrophilic/thermoresponsive, hydrophilic/pH-responsive and hydrophobic/metal chelating functionalities and oleic acid-coated magnetite nanoparticles, ...
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Mechanical properties of structurally-defined magnetoactive polymer (co)networks
Mpekris, F.; Achilleos, M.; Vasile, E.; Vasile, E.; Krasia-Christoforou, T.; Stylianopoulos, T. (2015)The mechanical properties of structurally-defined magnetoactive polymer (co)networks synthesized from well-defined poly(2-dimethylamino)ethyl methacrylate (poly(DMAEMA)) homopolymers and diblock copolymers of poly(DMAEMA) ...
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Conference Object
Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors
Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (Springer Verlag, 2016)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Pirfenidone normalizes the tumor microenvironment to improve chemotherapy
Polydorou, C.; Mpekris, F.; Papageorgis, P.; Voutouri, C.; Stylianopoulos, T. (2017)Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion ...
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Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...
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Role of vascular normalization in benefit from metronomic chemotherapy
Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...
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Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
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Article
Stress alleviation strategy in cancer treatment: Insights from a mathematical model
Mpekris, F.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T. (2018)Tumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels-while nourishing the tumor-are usually ...
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Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Structurally-defined semi-interpenetrating amphiphilic polymer networks with tunable and predictable mechanical response
Achilleos, M.; Mpekris, F.; Stylianopoulos, T.; Krasia-Christoforou, T. (2016)The synthesis of structurally-defined semi-interpenetrating amphiphilic networks is realized by employing an easy and versatile synthetic concept based on the encapsulation of well-defined hydrophobic linear polymer chains ...
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Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Papageorgis, P.; Polydorou, C.; Mpekris, F.; Voutouri, C.; Agathokleous, E.; Kapnissi-Christodoulou, C. P.; Stylianopoulos, T. (2017)Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...