Browsing by Author "Mpekris, Fotios"

Now showing items 1-9 of 9

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      Activin A Signaling Regulates IL13Rα2 Expression to Promote Breast Cancer Metastasis 

      Kalli, Maria; Mpekris, Fotios; Wong, Chen K.; Panagi, Myrofora; Ozturk, Sait; Thiagalingam, Sam; Stylianopoulos, Triantafyllos; Papageorgis, Panagiotis (2019)
      Metastatic dissemination of cancer cells to distal organs is the major cause of death for patients suffering from the aggressive basal-like breast cancer (BLBC) subtype. Recently, we have shown that interleukin 13 receptor ...
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      Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment 

      Martin, John D.; Panagi, Myrofora; Wang, Chenyu; Khan, Thahomina T.; Martin, Margaret R.; Voutouri, Chrysovalantis; Toh, Kazuko; Papageorgis, Panagiotis; Mpekris, Fotios; Polydorou, Christiana; Ishii, Genichiro; Takahashi, Shinichiro; Gotohda, Naoto; Suzuki, Toshiyuki; Wilhelm, Matthew E.; Melo, Vinicio Alejandro; Quader, Sabina; Norimatsu, Jumpei; Lanning, Ryan M.; Kojima, Motohiro; Stuber, Matthew David; Stylianopoulos, Triantafyllos; Kataoka, Kazunori; Cabral, Horacio (2019)
      Dexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various side effects of chemo-, radio-, and immunotherapies. Here, we ...
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      Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal 

      Papaphilippou, Petri Ch; Vyrides, Ioannis; Mpekris, Fotios; Stylianopoulos, Triantafyllos; Papatryfonos, Charalambos A.; Theocharis, Charis R.; Krasia‐Christoforou, Theodora (2015)
      Electrospun microfibrous membranes comprised of poly(methyl methacrylate)-poly((2-diethylamino)ethyl methacrylate) random copolymers (PMMA-co-PDEAEMA) of various chemical compositions blended together with a commercially ...
    • Article  

      Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies 

      Voutouri, Chrysovalantis; Kirkpatrick, Nathaniel D.; Chung, Euiheon; Mpekris, Fotios; Baish, James W.; Munn, Lance L.; Fukumura, Dai; Stylianopoulos, Triantafyllos; Jain, Rakesh K. (2019)
      Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can ...
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      Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma 

      Zhao, Yanxia; Cao, Jinghong; Melamed, Alexander; Worley, Michael; Gockley, Allison; Jones, Dennis; Nia, Hadi T.; Zhang, Yanling; Stylianopoulos, Triantafyllos; Kumar, Ashwin S.; Mpekris, Fotios; Datta, Meenal; Sun, Yao; Wu, Limeng; Gao, Xing; Yeku, Oladapo; Del Carmen, Marcela G.; Spriggs, David R.; Jain, Rakesh K.; Xu, Lei (2019)
      In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correlate with survival. We sought to enhance drug delivery and therapeutic efficacy by remodeling the ...
    • Article  

      NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression 

      Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)
      N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
    • Article  

      NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression 

      Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)
      N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
    • Article  

      Stress alleviation strategy in cancer treatment: Insights from a mathematical model 

      Mpekris, Fotios; Voutouri, Chrysovalantis; Papageorgis, Panagiotis; Stylianopoulos, Triantafyllos (2018)
      Tumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels—while nourishing the tumor—are usually ...
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      Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner 

      Papageorgis, P.; Polydorou, Christiana; Mpekris, Fotios; Voutouri, Chrysovalantis; Agathokleous, Eliana A.; Kapnissi‐Christodoulou, Constantina P.; Stylianopoulos, Triantafyllos (2017)
      Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...