Πλοήγηση ανά Συγγραφέα "Murley, J. S."
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Article
Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells
Constantinou, Andreas I.; Kamath, N.; Murley, J. S. (1998)The aim of this study was to identify the molecular mechanism of action of the isoflavone, genistein. Genistein at 0.15 mM caused MCF-7 apoptotic cell death, which was accompanied by cell cycle delay in the G2/M phase. ...
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Article
Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function
Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...
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Article
Inhibition of topoisomerase IIα activity in CHO K1 cells by 2- [(aminopropyl)amino]ethanethiol (WR-1065)
Grdina, D. J.; Constantinou, Andreas I.; Shigematsu, N.; Murley, J. S. (1994)The aminothiol 2-[(aminopropyl)amino]ethanethiol (WR-1065) is the active thiol of the clinically studied radioprotective agent S-2-(3- aminopropylamino)ethylphosphorothioic acid (WR-2721). WR-1065 is an effective radiation ...
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Article
WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells
Murley, J. S.; Constantinou, Andreas I.; Kamath, N. S.; Grdina, D. J. (1997)The effects of WR-1065 (2-((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. Exposure ...