Browsing by Author "Opal, Steven M."
Now showing items 1-7 of 7
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Estrogen receptor β agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study
Christaki, Eirini; Opal, Steven M.; Jr, James C. Keith; Kessimian, Nubar; Palardy, J. E.; Parejo, N. A.; LaVallie, Edward R.; Racie, L.; Mounts, W.; Malamas, Michael S.; Mewshaw, Richard E.; Harris, Heather A.; Vlasuk, G. P. (2010)Background. Nonsteroidal agonists have been developed that selectively bind to and activate estrogen receptor β (ERβ) rather than estrogen receptor α (ERα). ERβ is expressed equally in both male and female mammals in ...
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Immunomodulatory therapy for sepsis: An update
Christaki, Eirini; Anyfanti, Panagiota; Opal, Steven M. (2011)Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support ...
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Is the mortality rate for septic shock really decreasing?
Christaki, Eirini; Opal, Steven M. (2008)Survival rates for patients in septic shock have gradually improved in critical care units worldwide over the last 25 years. Further improvement will be predicated on the discovery of new therapies to disrupt the underlying ...
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A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia
Christaki, Eirini; Opal, Steven M.; Jr, James C. Keith; Kessimian, Nubar; Palardy, J. E.; Parejo, N. A.; Tan, X. Y.; Piche-Nicholas, N.; Tchistiakova, L.; Vlasuk, G. P.; Shields, K. M.; Feldman, Jeffrey L.; LaVallie, Edward R.; Arai, Maya; Mounts, W.; Pittman, D. D. (2011)The RAGE (receptor for advanced glycation end products) is believed to play a role in sepsis by perpetuating inflammation. The interaction of RAGE with a variety of host-derived ligands that accumulate during stress and ...
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NK and NKT cell depletion alters the outcome of experimental pneumococcal pneumonia: Relationship with regulation of interferon- γ production
Christaki, Eirini; Diza, Evdoxia; Giamarellos-Bourboulis, Evangelos J.; Papadopoulou, Nikoletta; Pistiki, Aikaterini; Droggiti, Dionysia-Irini; Georgitsi, Marianna; Machova, Alzbeta; Lambrelli, Dimitra; Malisiovas, Nicolaos; Nikolaidis, Pavlos; Opal, Steven M. (2014)Background. Natural killer (NK) and natural killer T (NKT) cells contribute to the innate host defense but their role in bacterial sepsis remains controversial. Methods. C57BL/6 mice were infected intratracheally with 5 × ...
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NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-gamma Production
Christaki, Eirini; Diza, Evdoxia; Giamarellos-Bourboulis, Evangelos J.; Papadopoulou, Nikoletta; Pistiki, Aikaterini; Droggiti, Dionysia-Irini; Georgitsi, Marianna; Machova, Alzbeta; Lambrelli, Dimitra; Malisiovas, Nicolaos; Nikolaidis, Pavlos; Opal, Steven M. (2015)Background. Natural killer (NK) and natural killer T (NKT) cells contribute to the innate host defense but their role in bacterial sepsis remains controversial. Methods. C57BL/6 mice were infected intratracheally with 5 x ...
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Receptor for advanced glycation end products in bacterial infection: Is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis?
Christaki, Eirini; Lazaridis, Nikolaos; Opal, Steven M. (2012)Purpose of review: Sepsis is still associated with excess morbidity and mortality worldwide, despite significant advances in critical care medicine. A novel approach is needed in the treatment of sepsis, one that will aim ...