Browsing by Author "Ostrovski, Yan"
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Article
Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
Ostrovski, Yan; Dorfman, Simon; Mezhericher, Maksim; Kassinos, Stavros; Sznitman, Josué (2019)The pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the ...
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Article
Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations
Shachar-Berman, Lihi; Ostrovski, Yan; Koshiyama, Kenichiro; Wada, Shigeo; Kassinos, Stavros C.; Sznitman, Josué (2019)Non-spherical particles, and fibers in particular, are potentially attractive airborne carriers for pulmonary drug delivery. Not only do they exhibit a high surface-to-volume ratio relative to spherical aerosols, but their ...
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Article
Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways
Shachar-Berman, Lihi; Ostrovski, Yan; De Rosis, Alessandro; Kassinos, Stavros; Sznitman, Josué (2018)It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their ...