Browsing by Author "Pezzuto, J. M."
Now showing items 1-13 of 13
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Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: Evidence for a potential role as a chemopreventive agent
Salti, G. I.; Kichina, J. V.; Das Gupta, T. K.; Uddin, S.; Bratescu, L.; Pezzuto, J. M.; Mehta, R. G.; Constantinou, Andreas I. (2001)Melanoma transformation progresses in a multistep fashion from precursor lesions such as congenital naevi. Exposure to ultraviolet (UV) light promotes this process. Betulinic acid (BA) was identified by our group as a ...
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Article
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles
Burdette, J. E.; Chen, S. -N; Lu, Z. -Z; Xu, H.; White, B. E. P.; Fabricant, D. S.; Liu, J.; Fong, H. H. S.; Farnsworth, N. R.; Constantinou, Andreas I.; Van Breemen, R. B.; Pezzuto, J. M.; Bolton, J. L. (2002)The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action. In an effort to determine if black cohosh had additional ...
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Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Thomas, C. F.; Hawthorne, M.; You, M.; Gerhäuser, C.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1995)Brassinin [3-(S-methyldithiocarbamoyl aminomethyl indole], a phytoalexin first identified as a constituent of cabbage, was synthesized and evaluated for cancer chemopreventive activity. Dose-dependent inhibition of ...
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Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats
Constantinou, Andreas I.; Lantvit, D.; Hawthorne, M.; Xu, X.; Van Breemen, R. B.; Pezzuto, J. M. (2001)There are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female rats, mainly because of different rodent models that are used in chemoprevention studies. The present study ...
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Erratum: Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase (Nature Medicine 1, 260-266, (1995))
Gerhauser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)
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Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms
Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...
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Article
A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health
Xu, H.; Fabricant, D. S.; Piersen, C. E.; Bolton, J. L.; Pezzuto, J. M.; Fong, H.; Totura, S.; Farnsworth, N. R.; Constantinou, Andreas I. (2002)Traditional taxonomic methods of botanical identification that rely primarily on morphological observations cannot be used efficiently when only powdered plant materials are available. Thus, our objectives were to determine ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase
Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Mehta, R. G.; Mar, W.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis
Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity
Cho, K. H.; Pezzuto, J. M.; Bolton, J. L.; Steele, V. E.; Kelloff, G. J.; Lee, S. K.; Constantinou, Andreas I. (2000)The present study was undertaken to determine if in vitro inhibition of one or both of the two most dominant mammalian DNA topoisomerases (topos) is common among chemopreventive agents. To determine if an agent was a topo ...
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Soy protein isolate prevents chemically-induced rat mammary tumors
Constantinou, Andreas I.; Morgan Lucas, L.; Lantvit, D.; Hawthorne, M.; Xu, X.; Chu, W. N.; Jeffery, E. H.; Christov, K.; Van Breemen, R. B.; Pezzuto, J. M. (2002)purified daidzein at 200 mg/kg diet
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Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Hawthorne, M.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1994)Brassinin, a pkytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective ...
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Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats
Burdette, J. E.; Liu, J.; Lantvit, D.; Lim, E.; Booth, N.; Bhat, K. P. L.; Hedayat, S.; Van Breemen, R. B.; Constantinou, Andreas I.; Pezzuto, J. M.; Farnsworth, N. R.; Bolton, J. L. (2002)Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones ...