Browsing by Author "Pierce, Karen"

Now showing items 1-5 of 5

    • Article  

      The ASD Living Biology: from cell proliferation to clinical phenotype 

      Courchesne, Eric; Pramparo, Tiziano; Gazestani, Vahid H.; Lombardo, Michael V.; Pierce, Karen; Lewis, Nathan E. (2019)
      Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, ...
    • Article  

      Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers 

      Pramparo, Tiziano; Lombardo,Michael V.; Campbell, Kathleen; Barnes, Cynthia Carter; Marinero, S.; Solso, S.; Young, Julia; Mayo, Maisi; Dale, Anders; Ahrens-Barbeau, Clelia; Murray, Sarah S.; Lopez, Linda; Lewis, Nathan E.; Pierce, Karen; Courchesne, Eric (2015)
      Genetic mechanisms underlying abnormal early neural development in toddlers with Autism Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene expression measurement during critical periods ...
    • Article  

      Different functional neural substrates for good and poor language outcome in autism 

      Lombardo,Michael V.; Pierce, Karen; Eyler, Lisa T.; CarterBarnes, C.; Ahrens-Barbeau, Clelia; Solso, S.; Campbell, Kathleen; Courchesne, Eric (2015)
      Autism (ASD) is vastly heterogeneous, particularly in early language development. While ASD language trajectories in the first years of life are highly unstable, by early childhood these trajectories stabilize and arepredictive ...
    • Article  

      Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes 

      Lombardo, Michael V.; Pramparo, Tiziano; Gazestani, Vahid; Warrier, Varun; Bethlehem, Richard A. I.; Carter Barnes, Cynthia; Lopez, Linda; Lewis, Nathan E.; Eyler, Lisa; Pierce, Karen; Courchesne, Eric (2018)
      Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple ...
    • Article  

      Prediction of autism by translation and immune/inflammation coexpressed genes in toddlers from pediatric community practices 

      Pramparo, Tiziano; Pierce, Karen; Lombardo,Michael V.; Barnes, Cynthia Carter; Marinero, S.; Ahrens-Barbeau, Clelia; Murray, Sarah S.; Lopez, Linda; Xu, R.; Courchesne, Eric (2015)
      Importance: The identification of genomic signatures that aid early identification of individuals at risk for autism spectrum disorder (ASD) in the toddler period remains a major challenge because of the genetic and ...