Browsing by Author "Pirentis, A. P."
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Conference Object
Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors
Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (Springer Verlag, 2016)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Article
Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Article
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
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Article
Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...