Browsing by Author "Runyan, C."
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Article
The Dietary Anticancer Agent Ellagic Acid is a Potent Inhibitor of DNA Topoisomerases in Vitro
Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Moon, R.; Stoner, G. D.; Rao, K. (1995)Ellagic acid and 12 related agents have been tested for their ability to inhibit the activities of human DNA topoisomerase (topo) I and IL Using specific in vitro assays, we found ellagic acid and flavellagic acid to be ...
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Article
Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships
Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Rao, K.; Vaughan, A.; Moon, R. (1995)Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. Myricetin, quercetin, fisetin, and morin were found to inhibit both enzymes, while phloretin, ...