Browsing by Author "Stylianopoulos, T."
Now showing items 1-20 of 93
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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness
Voutouri, C.; Stylianopoulos, T. (2018)Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major ...
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Alignment of electrospun polymer fibers using a concave collector
Savva, I.; Evaggelou, E.; Papaparaskeva, G.; Leontiou, T.; Stylianopoulos, T.; Mpekris, F.; Stylianou, K.; Krasia-Christoforou, T. (2015)During recent years, electrospinning has become a powerful technique for the cost-effective production of fibrous materials with diameters ranging from a few nanometers up to a few micrometers. In a conventional electrospinning ...
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Amphiphilic Polymer Conetworks Based on End-Linked "core-First" Star Block Copolymers: Structure Formation with Long-Range Order
Kepola, E. J.; Loizou, E.; Patrickios, C. S.; Leontidis, E.; Voutouri, C.; Stylianopoulos, T.; Schweins, R.; Gradzielski, M.; Krumm, C.; Tiller, J. C.; Kushnir, M.; Wesdemiotis, C. (2015)Amphiphilic polymer conetworks are cross-linked polymers that swell both in water and in organic solvents and can phase separate on the nanoscale in the bulk or in selective solvents. To date, however, this phase separation ...
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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
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Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components
Stylianou, A.; Stylianopoulos, T. (2016)Cancer cells have different characteristics from normal cells in terms of morphology, cell–cell interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix interactions. Although the clarification ...
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Benefits of vascular normalization are dose and time dependent - Letter
Huang, Y.; Stylianopoulos, T.; Duda, D. G.; Fukumura, D.; Jain, R. K. (2013)
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Biphasic modeling of brain tumor biomechanics and response to radiation treatment
Angeli, S.; Stylianopoulos, T. (2016)Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
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Conference Object
Biphasic, structure-based modeling of tissue equivalent mechanics
Barocas, V. Η; Chandran, P. L.; Stylianopoulos, T. (Affiliation: Department of Bioengineering, University of California, Berkeley, CA 94720, United StatesAffiliation: Department of Chemical Engineering, University of Minnesota, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, MN 55455, United StatesCorrespondence Address: Chandran, P.L.Department of Bioengineering, University of California, Berkeley, CA 94720, United States, 2007)
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Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
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Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
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Cell adhesion and matrix stiffness: Coordinating cancer cell invasion and metastasis
Gkretsi, V.; Stylianopoulos, T. (2018)Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's adhesome at cell-ECM adhesion sites and ...
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Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse
Stylianopoulos, T.; Martin, J. D.; Snuderl, M.; Mpekris, F.; Jain, S. R.; Jain, R. K. (2013)The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...
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Combining two strategies to improve perfusion and drug delivery in solid tumors
Stylianopoulos, T.; Jain, R. K. (2013)Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
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Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure
Chauhan, V.; Boucher, Y.; Ferrone, C.; Roberge, S.; Martin, J.; Stylianopoulos, T.; Bardeesy, N.; DePinho, R.; Padera, T.; Munn, L.; Jain, R. (2014)
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Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation
Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...
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Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis
Kalli, M.; Stylianopoulos, T. (2018)Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness ...
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Delivering nanomedicine to solid tumors
Jain, R. K.; Stylianopoulos, T. (2010)Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...
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Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies
Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
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Design considerations for nanotherapeutics in oncology
Stylianopoulos, T.; Jain, R. K. (2015)Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...
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Conference Object
Design rules for cancer nanomedicines
Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...