Browsing by Author "Stylianou, Andreas"
Now showing items 1-8 of 8
-
Article
AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level
Stylianou, Andreas; Lekka, Malgorzata; Stylianopoulos, Triantafyllos (2018)Cancer development and progression are closely associated with changes both in the mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix (ECM) structure, composition, and mechanics. In this ...
-
Article
Atomic force microscopy nano-characterization of 3D collagen gels with tunable stiffness
Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)As extracellular matrix (ECM) nano-characteristics play a crucial role in cell behavior, including cancer development and metastasis, several ECM in vitro models have been used in order to study cells behavior under different ...
-
Article
Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts
Stylianou, Andreas; Gkretsi, Vasiliki; Louca, Maria; Zacharia, Lefteris C.; Stylianopoulos, Triantafyllos (2019)In many solid tumours a desmoplastic reaction takes place, which results in tumour tissue stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as collagen, by stromal cells, mainly ...
-
Article
A discussion regarding the approximation of cylindrical and spherical shaped samples as half spaces in AFM nanoindentation experiments
Kontomaris, Stylianos-Vasileios; Stylianou, Andreas; Malamou, Anna; Stylianopoulos, Triantafyllos (2018)A common assumption of nanoidentation experiments is to consider the sample as an elastic half space due to the simplicity of the analysis regarding the Young’s modulus calculation. However, in the nano—dimensions a sample ...
-
Article
The link between educational expenditures and student learning outcomes: Evidence from Cyprus
Kyriakides, Leonidas; Stylianou, Andreas; Eliophotou, Maria (2019)The paper investigates the relationship between educational expenditures and student learning outcomes in the Republic of Cyprus. Using Multilevel Regression Analysis and Discriminant Function Analysis, we investigate the ...
-
Article
Managing the link between higher education and the labour market: perceptions of graduates in Greece and Cyprus
Menon, Maria Eliophotou; Argyropoulou, Eleftheria; Stylianou, Andreas (2018)The paper investigates the experience of employed higher education graduates in two countries with high rates of graduate unemployment. It examines the employment experience of graduates and their perceptions regarding the ...
-
Article
Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation
Louca, Maria; Stylianou, Andreas; Minia, Angeliki; Pliaka, Vaia; Alexopoulos, Leonidas G.; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) ...
-
Article
Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion
Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Background Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including ...