Browsing by Author "Tose, R."

Now showing items 1-2 of 2

    • Article  

      Characterization of the bifunctional opioid UFP505 

      Tose, R.; Dietis, Nikolas; McDonald, J.; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2010)
      Morphine is a gold standard analgesic acting at μ-opioid receptors (MOP) with analgesia accompanied by side-effects, for example, tolerance. If δ-opioid receptors (DOP) are blocked at the same time that MOP is activated, ...
    • Article  

      In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505 

      Dietis, Nikolas; Niwa, H.; Tose, R.; McDonald, J.; Ruggieri, V.; Filaferro, M.; Vitale, G.; Micheli, L.; Ghelardini, C.; Salvadori, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2018)
      Background and Purpose Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reducing side-effects. We have evaluated the mixed μ opioid receptor agonist/ δ opioid receptor antagonist ...