Browsing by Author "Woscholski, R."
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Article
Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes
Georgiades, Savvas N.; Mak, L. H.; Angurell, I.; Rosivatz, E.; Firouz Mohd Mustapa, M.; Polychroni, Christoulla; Woscholski, R.; Vilar, R. (2011)The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...
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Article
A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain
Mak, L. H.; Georgiades, Savvas N.; Rosivatz, E.; Whyte, G. F.; Mirabelli, M.; Vilar, R.; Woscholski, R. (2011)Inositol phospholipids have emerged as important key players in a wide variety of cellular functions. Among the seven existing inositol phospholipids, phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) has attracted much ...