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Browsing by Subject "Alkylating agent"

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    • Article  

      Axillary nodal metastases from carcinoma of unknown primary (CUPAx): A systematic review of published evidence 

      Pentheroudakis, George; Lazaridis, G.; Pavlidis, Nicholas (2010)
      Axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) represent a rare clinical entity without consensus on its biology, management and outcome. We systematically ...

    • Article  

      Cancer, fertility and pregnancy: ESMO Clinical Recommendations for diagnosis, treatment and follow-up 

      Pentheroudakis, George; Pavlidis, Nicholas; Castiglione, M. (2009)

    • Article  

      Coexistence of pregnancy and malignancy 

      Pavlidis, Nicholas (2002)
      Cancer complicating pregnancy is a rare coexistence. The incidence is approximately 1 in 1,000 pregnancies. The most common cancers are those more frequently seen during the reproductive age of a woman. Breast cancer, ...

    • Article  

      Juvenile cancer: Improving care for adolescents and young adults within the frame of medical oncology 

      Pentheroudakis, George; Pavlidis, Nicholas (2005)
      Despite unique tumour epidemiology, a higher cancer incidence and modest survival improvement compared to paediatric patients, adolescents and young adults aged 15-30 have not been considered as a separate, 'special' group ...

    • Article  

      Lung cancer during pregnancy: An emerging issue 

      Pavlidis, Nicholas (2008)

    • Article  

      Management of patients with recurrent/advanced cervical cancer beyond first line platinum regimens: Where do we stand? A literature review 

      Boussios, Stergios; Seraj, E.; Zarkavelis, George; Petrakis, Dimitrios; Kollas, Aristomenes; Kafantari, Aikaterini; Assi, A.; Tatsi, K.; Pavlidis, Nicholas; Pentheroudakis, George (2016)
      Background Cervical cancer is the fourth most common cancer affecting women worldwide. Despite advances in screening and human papillomavirus (HPV) vaccination, a significant number of women present with or develop advanced ...

    • Article  

      Phase I trial of 6-hour infusion of glufosfamide, a new alkylating agent with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters: A study of the European Organization for Research and Treatment of Cancer Early Clinical Studies Group 

      Briassoulis, E. Ch; Judson, Ian Robert; Pavlidis, Nicholas; Beale, P.; Wanders, J.; Groot, Y.; Veerman, G.; Schuessler, M.; Niebch, G.; Siamopoulos, K. C.; Tzamakou, E.; Rammou, D.; Wolf, L.; Walker, R.; Hanauske, A. R. (2000)
      Purpose: To determine the maximum-tolerated dose (MTD), the principal toxicities, and the pharmacokinetics of 6-hour infusion of glufosfamide (beta-D-glucosylisophosphoramide mustard; D-19575), a novel alkylating agent ...

    • Article  

      Population pharmacokinetics and dynamics in phase II studies of the novel bioreductive alkylating cytotoxic indoloquinone EO9 

      Schellens, J. H. M.; Dombernowsky, P.; Cassidy, J.; Epelbaum, R.; Dirix, L.; Cox, E. H.; Wanders, J.; Calabresi, F.; Paridaens, R.; Monfardini, S.; Wolff, J.; Loos, W. J.; Verweij, J.; Pavlidis, Nicholas; Hanauske, A. R. (2001)
      Population pharmacokinetic-dynamic analysis was prospectively integrated in the clinical phase II programme of EO9 to determine the population pharmacokinetic profile in a larger population of patients, to estimate individual ...

    • Article  

      The pregnant mother with breast cancer: Diagnostic and therapeutic management 

      Pavlidis, Nicholas; Pentheroudakis, George (2005)
      This review describes the epidemiology, pathology, clinical picture and therapeutic management of pregnant women with breast cancer. In addition, it covers other important issues like the safety of both diagnostic and ...

    • Article  

      Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: A matched controlled study 

      Halaska, M. J.; Pentheroudakis, George; Strnad, P.; Stankusova, H.; Chod, J.; Robova, H.; Petruzelka, L.; Rob, L.; Pavlidis, Nicholas (2009)
      Pregnancy-associated breast cancer (PABC) is a rare and challenging problem. We sought to describe epidemiology, management and outcome of women in whom breast cancer was diagnosed during pregnancy or within one year after ...

    • Article  

      Prognostic factors in glioblastoma patients managed with radiotherapy combined with temozolomide 

      Peponi, Evangelia; Toumpoulis, Ioannis K.; Tasiou, I.; Pavlidis, Nicholas; Pentheroudakis, George; Tsekeris, P. (2014)
      Purpose: No consensus on clinicopathologic prognostic factors that predict the outcome of patients with newly diagnosed glioblastoma multiforme (GBM) managed with resection, postoperative radiotherapy (RT) and adjuvant ...

    • Article  

      Rituximab in combination with CNOP chemotherapy in patients withn previously untreated indolent non-Hodgkin's lymphoma 

      Economopoulos, T.; Fountzilas, George; Pavlidis, Nicholas; Kalantzis, Dimitrios; Papageorgiou, E.; Christodoulou, C.; Hamilos, G.; Nikolaides, C.; Dimopoulos, M. A. (2003)
      Rituximab, a chimeric monoclonal antibody, produces response rates of up to 73% in patients with previously untreated indolent non-Hodgkin's lymphoma (NHL), and has high activity when combined with chemotherapy. The purpose ...

    • Article  

      Serous papillary peritoneal carcinoma: Unknown primary tumour, ovarian cancer counterpart or a distinct entity? A systematic review 

      Pentheroudakis, George; Pavlidis, Nicholas (2010)
      Introduction: Serous peritoneal papillary carcinoma (SPPC), though managed according to ovarian cancer therapeutic principles, has been variably considered as an ovarian cancer counterpart, a peritoneal malignancy with ...

    • Article  

      Systemic treatment-induced gastrointestinal toxicity: Incidence, clinical presentation and management 

      Boussios, Stergios; Pentheroudakis, George; Katsanos, K.; Pavlidis, Nicholas (2012)
      The toxicity of cancer chemotherapy is among the most important factors limiting its use. Clear delineation and communication of benefits and risks is an essential component of treatment decisions. Gastrointestinal toxicity ...

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