Browsing by Subject "Angiogenesis"

Article

Cancer of unknown primary site: Missing primary or missing biology?

Pentheroudakis, George; Briassoulis, E. Ch; Pavlidis, Nicholas (2007)

Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer deaths and represents both a diagnostic and a management challenge. In CUP, the regression or dormancy of the primary tumor, the development ...

Article

Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma

Karavasilis, V.; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Tsanou, E.; Kitsou, E.; Pavlidis, Nicholas (2006)

The aim of the study was to investigate angiogenesis in patients with advanced-stage ovarian carcinoma. We used paraffin-embedded tumor tissues from 33 patients diagnosed with FIGO III ovarian cancer who had optimal surgery ...

Article

Dose-ranging study of metronomic oral vinorelbine in patients with advanced refractory cancer

Briassoulis, E. Ch; Pappas, P.; Puozzo, C.; Ch, F. Tolis; Fountzilas, George; Dafni, U.; Marselos, M.; Pavlidis, Nicholas (2009)

Aim: To determine the safe dose range and pharmacokinetics of metronomic oral vinorelbine and obtain preliminary data on biomarkers and efficacy in patients with advanced cancer. Methods: Successive cohorts ofpatients ...

Article

The evolution of systemic therapy in sarcoma

Constantinidou, Anastasia; Pollack, S. M.; Loggers, Elizabeth; Rodler, E.; Jones, Robin Lewis (2013)

Approximately 50% of patients with localized soft tissue sarcomas will develop recurrent disease after complete surgical resection, requiring alternative means of treatment. Conventional chemotherapy comprising of doxorubicin ...

Article

Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks

Kamposioras, K.; Pentheroudakis, George; Pavlidis, Nicholas (2013)

Background: Cancer of unknown primary (CUP) ranks among the ten most common malignancies worldwide. Cancer of unknown primary presents as disseminated disease, has a dismal prognosis and remains a diagnosis of exclusion. ...

Article

Forty years experience of treating cancer of unknown primary

Pavlidis, Nicholas (2007)

Cancer of unknown primary site (CUP) is not a rare tumour. It accounts as the seventh to eighth most frequently diagnosed cancer in a general medical oncology service. Since CUP is not a homogeneous disease and it consists ...

Article

The prognostic evaluation of tumor angiogenesis in invasive breast carcinoma

Ioachim, E.; Charchanti, A.; Charalabopoulos, K.; Tsanou, E.; Briassoulis, E. Ch; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2002)

Microvessel density (MVD) was analyzed for associations with clinical and pathological factors as well as with other potential known prognostic factors such as: steroid receptor content (ER, PgR), p53 and proliferation ...

Article

Prognostic utility of angiogenesis and hypoxia effectors in patients with operable squamous cell cancer of the larynx

Pentheroudakis, George; Nicolaou, I.; Kotoula, V.; Fountzilas, E.; Markou, K.; Eleftheraki, A. G.; Fragkoulidi, A.; Karasmanis, I.; Tsigka, A.; Angouridakis, N.; Vlachtsis, K.; Nikolaou, A.; Pavlidis, Nicholas; Fountzilas, George (2012)

Angiogenesis is active in localised laryngeal squamous cell carcinoma. We assessed relative messenger RNA (mRNA) and immunohistochemical (IHC) expression of Vascular Endothelial Growth Factors (VEGF) A, B, C, their receptors ...

Article

Transcriptional activity of human epidermal growth factor receptor family and angiogenesis effectors in locoregionally recurrent head and neck squamous cell carcinoma and correlation with patient outcome

Pentheroudakis, George; Angouridakis, N.; Wirtz, R. M.; Nikolaou, A.; Kalogeras, K. T.; Pavlidis, Nicholas; Fountzilas, George (2009)

Locoregional recurrence is the most common failure pattern in patients with head and neck squamous cell carcinoma (HNSCC). We retrospectively identified 41 HNSCC patients with locoregional relapse and used kinetic reverse ...