Browsing by Subject "Apoptosis"

Article

Antirestenotic effects of a novel polymer-coated d-24851 eluting stent. Experimental data in a rabbit iliac artery model

Lysitsas, Dimitrios N.; Katsouras, Christos S.; Papakostas, John C.; Toumpoulis, Ioannis K.; Angelidis, Charalampos; Bozidis, Petros; Thomas, Christopher G.; Seferiadis, C.; Psychoyios, Nikolaos; Frillingos, Stathis; Pavlidis, Nicholas; Marinos, Euaggelos; Khaldi, Lubna; Sideris, Dimitris A.; Michalis, Lampros K. (2007)

Experimental and clinical data suggest that stents eluting antiproliferative agents can be used for the prevention of in-stent restenosis. Here we investigate in vitro the antiproliferative and apoptotic effect of D-24851 ...

Article

Apoptosis and hepatitis C virus infection in renal transplant recipients

Delladetsima, I.; Psichogiou, M.; Alexandrou, P.; Nikolopoulos, Georgios K.; Revenas, K.; Hatzakis, A.; Boletis, J. (2008)

Hepatocellular injury in renal transplant recipients with hepatitis C virus (HCV) infection remains unclear. The suppressed immune response, in combination with increased viremia levels, provides a unique setting for the ...

Article

Association of Fokl and PvuII polymorphisms with breast cancer staging and survival among Caucasian women: A prospective study

Yiallourou, Anneza I.; Ekonomou, Emmanouel; Tsamadias, V.; Nastos, Constantinos; Karapanos, Konstantinos; Papaconstantinou, Ioannis; Theodosopoulos, Theodosios; Contis, John; Papalarabros, E.; Voros, Dionysios; Psychogios, J. (2014)

Purpose: Both vitamin D and estrogens play an important role in breast cell growth and differentiation. Therefore, we hypothesized that Fokl polymorphism in the Vitamin D Receptor (VDR) gene, as well as PvuII polymorphism ...

Article

Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer

Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)

Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...

Article

Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27Kip1-dependent G1/S cell cycle arrest in conjunction with NF-κB activation

Batsi, Christina; Markopoulou, Soultana; Kontargiris, Evangelos; Charalambous, Christina; Thomas, Christoforos G.; Christoforidis, Savvas; Kanavaros, Panagiotis E.; Constantinou, Andreas I.; Marcu, Kenneth B.; Kolettas, Evangelos (2009)

2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain ...

Article

Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. A Hellenic co-operative oncology group study

Briassoulis, E. Ch; Tsokos, M.; Fountzilas, George; Bafaloukos, Dimitrios; Kosmidis, Paraskevas A.; Samantas, E.; Skarlos, Dimosthenis V.; Nikolaides, C.; Pavlidis, Nicholas (1998)

We have previously shown that metastatic carcinomas of unknown primary site overexpress several tumor markers as well as the products of the oncogenes c-myc, ras and c-erbB2. We analysed the tissue expression of the protein ...

Book Chapter

Breast Cancer Epigenetics

Pitta, Chara A.; Constantinou, Andreas I. (Elsevier Inc., 2015)

The molecular mechanisms underlying the development and progression of breast cancer are far from being understood. It is obvious that the initiation of breast cancer as well as its transition toward distinct breast cancer ...

Article

Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy?

Constantinou, Constantina; Papas, Konstantinos A.; Constantinou, Andreas I. (2009)

In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ...

Article

Chemotherapy cytotoxicity of human MCF-7 and MDA-MB 231 breast cancer cells is altered by osteoblast-derived growth factors

Koutsilieris, M.; Reyes-Moreno, C.; Choki, I.; Sourla, A.; Doillon, C.; Pavlidis, Nicholas (1999)

One-third of women with breast cancer will develop bone metastases and eventually die from disease progression at these sites. Therefore, we analyzed the ability of human MG-63 osteoblast-like cells (MG-63 cells), MG- 63 ...

Article

The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host

Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)

Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...

Article

Correlation between increased serum sFas levels and microalbuminuria in type 1 diabetic patients

Protopsaltis, J.; Kokkoris, Stelios; Nikolopoulos, Georgios K.; Spyropoulou, P.; Katsaros, T.; Salvanos, L.; Brestas, Paris; Korantzopoulos, Panagiotis; Melidonis, Andreas (2007)

Objective: The aim of this study was to elucidate if apoptosis dysregulation is present in type 1 diabetic patients with microalbuminuria. Subjects and Methods: The following variables were determined in 29 type 1 diabetic ...

Article

D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells

Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)

d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...

Article

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway

Pavlou, Demos; Kirmizis, Antonis (2016)

Protein N-terminal acetylation is an abundant post-translational modification in eukaryotes implicated in various fundamental cellular and biochemical processes. This modification is catalysed by evolutionarily conserved ...

Article

Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells

Charalambous, Christina; Pitta, Chara A.; Constantinou, Andreas I. (2013)

Background: Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer ...

Article

A fragment of the alarmin prothymosin α as a novel biomarker in murine models of bacteria-induced sepsis

Samara, Pinelopi; Miriagou, Vivì; Zachariadis, Michael; Mavrofrydi, Olga; Promponas, Vasilis J.; Dedos, Skarlatos G.; Papazafiri, Panagiota; Kalbacher, H.; Voelter, W.; Tsitsilonis, Ourania E. (2017)

Sepsis is a life-threatening condition that requires urgent care. Thus, the identification of specific and sensitive biomarkers for its early diagnosis and management are of clinical importance. The alarmin prothymosin ...

Article

Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells

Constantinou, Andreas I.; Kamath, N.; Murley, J. S. (1998)

The aim of this study was to identify the molecular mechanism of action of the isoflavone, genistein. Genistein at 0.15 mM caused MCF-7 apoptotic cell death, which was accompanied by cell cycle delay in the G2/M phase. ...

Article

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells

Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)

The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells

Article

Host immune response in sepsis due to ventilator-associated pneumonia: How is it different?

Christaki, Eirini (2009)

Current evidence regarding potentially different host response mechanisms in sepsis according to the type of initiating infection is sporadic. It is possible that alterations in cell populations, variations in effector ...

Article

Immunomodulatory therapy for sepsis: An update

Christaki, Eirini; Anyfanti, Panagiota; Opal, Steven M. (2011)

Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support ...

Article

In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants

Righi, V.; Apidianakis, Yiorgos; Psychogios, N.; Rahme, L. G.; Tompkins, R. G.; Tzika, A. A. (2014)

In vivo nuclear magnetic resonance spectroscopy (NMR), a non-destructive biochemical tool used for investigating live organisms, has recently been performed in studies of the fruit fly Drosophila melanogaster, a useful ...