• Article  

      Alexithymia in children with and without autism spectrum disorders 

      Griffin, Cait; Lombardo, Michael V.; Auyeung, Bonnie (2016)
      Alexithymia refers to pronounced difficulty in identifying and describing one's own emotions and is associated with an externally oriented focus of thinking. Alexithymia is known to be much more common in adults with autism ...
    • Article  

      Atypical neural self-representation in autism 

      Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Suckling,John; Baron-Cohen,Simon (2010)
      The 'self' is a complex multidimensional construct deeply embedded and in many ways defined by our relations with the social world. Individuals with autism are impaired in both self-referential and other-referential social ...
    • Article  

      Biological sex affects the neurobiology of autism 

      Lai,Meng-Chuan; Lombardo,Michael V.; Suckling,John; Ruigrok,Amber N. V.; Chakrabarti,B.; Ecker,C.; Deoni,Sean C. L.; Craig, Michael C.; Murphy,Declan G. M.; Bullmore,Edward T.; Baron-Cohen,Simon (2013)
      In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females ...
    • Article  

      Brain and behavioral correlates of action semantic deficits in autism 

      Moseley, Rachel L.; Mohr, Bettina; Lombardo,Michael V.; Baron-Cohen,Simon; Hauk, Olaf; Pulvermueller, Friedemann (2013)
      Action-perception circuits containing neurons in the motor system have been proposed as the building blocks of higher cognition; accordingly, motor dysfunction should entail cognitive deficits. Autism spectrum conditions ...
    • Article  

      Decreased centrality of cortical volume covariance networks in autism spectrum disorders 

      Balardin, J. B.; Comfort, W. E.; Daly, Eileen M.; Murphy, Clodagh M.; Andrews, Derek Sayre; Murphy, Declan G. M.; Ecker, C.; Sato, J. R.; Bailey, Anthony J.; Baron-Cohen, Simon; Bolton, P. F.; Bullmore, Edward T.; Carrington, S.; Catani, Marco; Chakrabarti, B.; Craig, Michael C.; Daly, Eileen M.; Deoni, Sean C. L.; Happé, Francesca; Henty, Julian; Jezzard, Peter; Johnston, Patrick; Jones, D. K.; Lai, Meng-Chuan; Lombardo, Michael V.; Madden, A.; Mullins, D.; Murphy, Clodagh M.; Murphy, Declan G. M.; Pasco, Greg; Ruigrok, Amber N. V.; Sadek, Susan A.; Spain, D.; Stewart, R.; Suckling, John; Wheelwright, Sally J.; Williams, Steven C. R.; Wilson, C. E.; MRC AIMS Consortium (2015)
      Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by atypical structural and functional brain connectivity. Complex network analysis has been mainly used to describe altered ...
    • Article  

      The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation 

      Charman, T.; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, C.; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen,Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Y.; Chakrabarti,B.; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, G.; Durston, Sarah; Ecker,C.; Faulkner, J.; Frouin, Vincent; Garces, Pilar; Ham, Lindsay M.; Hayward, Hannah; Hipp, Joerg; Holt, R. J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai,Meng-Chuan; D'Ardhuy, X. L.; Lombardo,Michael V.; Lythgoe, David J.; Mandl, Rene; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan J.; Persico, Antonio M.; Ruggeri, B.; Ruigrok,Amber N. V.; Sabet, Jessica; Sacco, Roberto; Caceres, Antonia San Jose; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams,Steven C. R.; Zwiers, Marcel P.; Spooren, Will; Murphy,Declan G. M.; Buitelaar, Jan K. (2017)
      Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes ...
    • Article  

      Hierarchical cortical transcriptome disorganization in autism 

      Lombardo,Michael V.; Courchesne, Eric; Lewis, Nathan E.; Pramparo, Tiziano (2017)
      Background: Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell ...
    • Article  

      Imaging sex/gender and autism in the brain: Etiological implications 

      Lai,Meng-Chuan; Lerch, Jason P.; Floris, Dorothea L.; Ruigrok,Amber N. V.; Pohl, A.; Lombardo,Michael V.; Baron-Cohen,Simon (2017)
      The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform ...
    • Article  

      Impaired Communication Between the Motor and Somatosensory Homunculus Is Associated With Poor Manual Dexterity in Autism Spectrum Disorder 

      Thompson, A.; Murphy,Clodagh M.; Dell’Acqua, Flavio; Ecker,C.; McAlonan, Grainne; Howells, Henrietta; Baron-Cohen,Simon; Lai,Meng-Chuan; Lombardo,Michael V. (2017)
      Background Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are ...
    • Article  

      Lost for emotion words: What motor and limbic brain activity reveals about autism and semantic theory 

      Moseley, Rachel L.; Shtyrov, Yury; Mohr, Bettina; Lombardo,Michael V.; Baron-Cohen,Simon; Pulvermueller, Friedemann (2015)
      Autism spectrum conditions (ASC) are characterised by deficits in understanding and expressing emotions and are frequently accompanied by alexithymia, a difficulty in understanding and expressing emotion words. Words are ...
    • Article  

      Moral dilemmas film task: A study of spontaneous narratives by individuals with autism spectrum conditions 

      Barnes, Jennifer L.; Lombardo, Michael V.; Wheelwright, Sally J.; Baron-Cohen, Simon (2009)
      People with autism spectrum conditions (ASC) have difficulties with mentalizing, empathy, and narrative comprehension. A new test of social and narrative cognition, the Moral Dilemmas Film Task, was developed to probe ...
    • Article  

      Neuroanatomy of individual differences in language in adult males with autism 

      Lai,Meng-Chuan; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Suckling,John; Bullmore,Edward T.; Happé,Francesca; Murphy,Declan G. M.; Baron-Cohen,Simon (2015)
      One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural ...
    • Article  

      Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay 

      Balardin, J. B.; Sato, J. R.; Vieira, G.; Feng, Yue; Daly,Eileen M.; Murphy,Clodagh M.; Bailey, Anthony J.; Carrington, S.; Jezzard, Peter; Stewart, R.; Baron-Cohen,Simon; Bullmore,Edward T.; Chakrabarti,B.; Henty, Julian; Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Suckling,John; Wheelwright,Sally J.; Bolton, P. F.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Spain,D.; Williams,Steven C. R.; Wilson, C. E.; Murphy,Clodagh M. (2015)
      Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the ...
    • Article  

      The role of the self in mindblindness in autism 

      Lombardo,Michael V.; Baron-Cohen,Simon (2011)
      Since its inception the 'mindblindness' theory of autism has greatly furthered our understanding of the core social-communication impairments in autism spectrum conditions (ASC). However, one of the more subtle issues ...
    • Article  

      Self-referential and social cognition in a case of autism and agenesis of the corpus callosum 

      Lombardo,Michael V.; Chakrabarti,B.; Lai,Meng-Chuan; Baron-Cohen,Simon (2012)
      Background: While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the ...
    • Article  

      Sex/Gender Differences and Autism: Setting the Scene for Future Research 

      Lai,Meng-Chuan; Lombardo,Michael V.; Auyeung, Bonnie; Chakrabarti,B.; Baron-Cohen,Simon (2015)
      Objective The relationship between sex/gender differences and autism has attracted a variety of research ranging from clinical and neurobiological to etiological, stimulated by the male bias in autism prevalence. Findings ...
    • Article  

      A shift to randomness of brain oscillations in people with autism 

      Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Bullmore,Edward T.; Baron-Cohen,Simon; Suckling,John (2010)
      Background Resting-state functional magnetic resonance imaging (fMRI) enables investigation of the intrinsic functional organization of the brain. Fractal parameters such as the Hurst exponent, H, describe the complexity ...
    • Article  

      Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism 

      Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Baron-Cohen,Simon (2011)
      Over the last 25 years, "mindblindness" (deficits in representing mental states) has been one of the primary explanations behind the hallmark social-communication difficulties in autism spectrum conditions (ASC). However, ...
    • Article  

      A typically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay 

      Floris, Dorothea L.; Lai,Meng-Chuan; Auer, Tibor; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Wheelwright,Sally J.; Bullmore,Edward T.; Murphy,Declan G. M.; Baron-Cohen,Simon; Suckling,John (2016)
      In humans, both language and fine motor skills are associated with left-hemisphere specialization, whereas visuospatial skills are associated with right-hemisphere specialization. Individuals with autism spectrum conditions ...
    • Article  

      White-matter relaxation time and myelin water fraction differences in young adults with autism 

      Deoni,Sean C. L.; Zinkstok, J. R.; Daly,Eileen M.; Ecker,C.; Williams,Steven C. R.; Murphy,Declan G. M.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2015)
      Background. Increasing evidence suggests that autism is associated with abnormal white-matter (WM) anatomy and impaired brain 'connectivity'. While myelin plays a critical role in synchronized brain communication, its ...