Browsing by Subject "Bifunctional opioids"
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(2010)Morphine is a gold standard analgesic acting at μ-opioid receptors (MOP) with analgesia accompanied by side-effects, for example, tolerance. If δ-opioid receptors (DOP) are blocked at the same time that MOP is activated, ...
(2012)BackgroundWhile producing good-quality analgesia,-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of δ-opioid (DOP) receptors has been shown to reduce tolerance ...