Browsing by Subject "Bifunctional opioids"

Now showing items 1-2 of 2

    • Article  

      Characterization of the bifunctional opioid UFP505 

      Tose, R.; Dietis, Nikolas; McDonald, J.; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2010)
      Morphine is a gold standard analgesic acting at μ-opioid receptors (MOP) with analgesia accompanied by side-effects, for example, tolerance. If δ-opioid receptors (DOP) are blocked at the same time that MOP is activated, ...
    • Article  

      Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505) 

      Dietis, Nikolas; McDonald, J.; Molinari, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2012)
      BackgroundWhile producing good-quality analgesia,-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of δ-opioid (DOP) receptors has been shown to reduce tolerance ...