• Doctoral Thesis  Open Access

      Accelerating bioinformatics and biomedical applications via massively parallel and reconfigurable systems 

      Papadopoulos, Agathoklis I. (Πανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering, 2014-12)
      Οι συνεχείς προσπάθειες για βελτίωση της παρεχόμενης ιατροφαρμακευτικής περίθαλψης μέσω καλύτερων τεχνικών διάγνωσης, παρακολούθησης και θεραπείας και κατά συνέπεια της βελτίωσης του βιοτικού επιπέδου της σύγχρονης κοινωνίας, ...
    • Conference Object  

      An adaptive multiscale AM-FM texture analysis system with application to hysteroscopy imaging 

      Constantinou, Ioannis P.; Pattichis, Marios S.; Tanos, Vasilios; Neofytou, Marios S.; Pattichis, Constantinos S. (2012)
      The use of multiscale AM-FM analysis systems has been recently demonstrated in a variety of applications in medical image analysis. In all of these applications, a fixed filter-bank is used as a preprocessing step for ...
    • Article  

      Application of abductive ILP to learning metabolic network inhibition from temporal data 

      Tamaddoni-Nezhad, A.; Chaleil, R.; Kakas, Antonis C.; Muggleton, S. (2006)
      In this paper we use a logic-based representation and a combination of Abduction and Induction to model inhibition in metabolic networks. In general, the integration of abduction and induction is required when the following ...
    • Conference Object  

      Assessment of the risk of coronary heart event based on data mining 

      Karaolis, Minas A.; Moutiris, Joseph Antoniou; Pattichis, Constantinos S. (2008)
      Coronary heart disease (CHD) is a major cause of morbidity and mortality in the western world. Although significant progress has been made in the diagnosis and treatment of CHD, further investigation is still needed. The ...
    • Article  

      Bagging multiple comparisons from microarray data 

      Politis, Dimitris Nicolas (2008)
      Bagging and subagging procedures are put forth with the purpose of improving the discovery power in the context of large-scale simultaneous hypothesis testing. Bagging and subagging significantly improve discovery power ...
    • Conference Object  

      A binary format for genetic data designed for large whole genome studies that enable both marker and strand based analyses 

      Antoniades, Athos; Loizou, L.; Aristodimou, Aristos; Pattichis, Constantinos S. (2008)
      Recent advances in genotyping technology have enabled large studies with data from thousands of subjects to contain half a million or more of single nucleotide polymorphisms (SNPs) marker per subject. This rapid increase ...
    • Article  

      BioTextQuest+: a knowledge integration platform for literature mining and concept discovery 

      Papanikolaou, Nikolas; Pavlopoulos, Georgios A.; Pafilis, Evangelos; Theodosiou, Theodosios G.; Schneider, Reinhard; Satagopam, Venkata P.; Ouzounis, Christos A.; Eliopoulos, Aristides G.; Promponas, Vasilis J.; Iliopoulos, Ioannis Crete (2015)
    • Conference Object  

      Clustering subjects in genetic studies with self organizing maps 

      Aristodimou, Aristos; Antoniades, Athos; Pattichis, Constantinos S. (2012)
      Several machine learning techniques have been applied for finding multi-loci associations among Single Nucleotide Polymorphisms (SNPs) and a disease. In this paper it is investigated whether Self Organizing Maps (SOMs) can ...
    • Conference Object  

      Combination of different texture features for mammographic breast density classification 

      Liasis, G.; Pattichis, Constantinos S.; Petroudi, Styliani (2012)
      Mammographic breast density refers to the prevalence of fibroglandular tissue as it appears on a mammogram. Breast density is not only an important risk for developing breast cancer but can also mask abnormalities. Breast ...
    • Article  

      A comparative study on filtering protein secondary structure prediction 

      Kountouris, P.; Agathocleous, Michalis; Promponas, Vasilis J.; Christodoulou, Georgia; Hadjicostas, S.; Vassiliades, Vassilis; Christodoulou, Chris C. (2012)
      Filtering of Protein Secondary Structure Prediction (PSSP) aims to provide physicochemically realistic results, while it usually improves the predictive performance. We performed a comparative study on this challenging ...
    • Conference Object  

      Design rules for cancer nanomedicines 

      Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)
      The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...
    • Conference Object  

      Despeckle filtering in ultrasound video of the common carotid artery 

      Loizou, Christos P.; Kasparis, Takis; Christodoulides, Paul; Theofanous, Charoula; Pantzaris, Marios C.; Kyriacou, Efthyvoulos C.; Pattichis, Constantinos S. (2012)
      Noise reduction is essential for increasing the visual quality or as a preprocessing step for further automated analysis in video sequences and video coding. The objective of this work was to investigate four different ...
    • Doctoral Thesis  Open Access

      Development of algorithms and software for unravelling the biological role of low complexity regions in protein sequences 

      Kirmitzoglou, Ioannis K. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2014-09)
      Πολλές πρωτεΐνες είναι εμπλουτισμένες σε περιοχές με ακραία αμινοξική σύσταση. Έχει δειχθεί ότι τέτοιες πρωτεΐνες διαδραματίζουν σημαντικούς βιολογικούς ρόλους αλλά, λόγω των ιδιαίτερων βιοχημικών ιδιοτήτων τους, η μελέτη ...
    • Conference Object  

      The effects of applying cell-suppression and perturbation to aggregated genetic data 

      Antoniades, Athos; Keane, J.; Aristodimou, Aristos; Philipou, Christa; Constantinou, Andreas I.; Georgousopoulos, Christos; Tozzi, Federica; Kyriacou, Kyriacos C.; Hadjisavvas, Andreas; Loizidou, Maria A.; Demetriou, Christiana A.; Pattichis, Constantinos S. (2012)
      The key test for confidence in any association discovered within the medical domain is replication testing. That is, the ability of the association to be detected in independent populations. At the same time, in order to ...
    • Article  

      Fine-grain parallelism using multi-core, Cell/BE, and GPU systems 

      Pratas, F.; Trancoso, Pedro; Sousa, L.; Stamatakis, A.; Shi, G.; Kindratenko, V. (2012)
      Currently, we are facing a situation where applications exhibit increasing computational demands and where a large variety of parallel processor systems are available. In this paper we focus on exploiting fine-grain ...
    • Conference Object  

      Fine-grain parallelism using multi-core, cell/BE, and GPU systems: Accelerating the phylogenetic likelihood function 

      Pratas, F.; Trancoso, Pedro; Stamatakis, A.; Sousa, L. (2009)
      We are currently faced with the situation where applications have increasing computational demands and there is a wide selection of parallel processor systems. In this paper we focus on exploiting fine-grain parallelism ...
    • Article  

      First Trimester Noninvasive Prenatal Diagnosis: A Computational Intelligence Approach 

      Neocleous, Andreas C.; Nicolaides, Kypros H.; Schizas, Christos N. (2016)
      The objective of this study is to examine the potential value of using machine learning techniques such as artificial neural network (ANN) schemes for the noninvasive estimation, at 11-13 weeks of gestation, the risk for ...
    • Article  

      Genomic approaches that aid in the identification of transcription factor target genes 

      Kirmizis, Antonis; Farnham, P. J. (2004)
      It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...
    • Conference Object  

      Head posture influences the geometric and hemodynamic features on the healthy human carotid bifurcation 

      Aristokleous, Nicolas; Seimenis, Ioannis; Papaharilaou, Yannis; Khozeymeh, M. I.; Georgiou, Georgios C.; Brott, B. C.; Anayiotos, Andreas S. (2012)
      Atherosclerosis is the third leading cause of morbidity and mortality in the Western world. Low and oscillating wall shear stress (WSS) regions have been previously reported as parameters that correlate with the development ...
    • Article  

      Initial experiences porting a bioinformatics application to a graphics processor 

      Charalambous, Maria; Trancoso, Pedro; Stamatakis, A. (2005)
      Bioinformatics applications are one of the most relevant and compute-demanding applications today. While normally these applications are executed on clusters or dedicated parallel systems, in this work we explore the use ...