• Article  

      A Biophysical Model of Endocannabinoid-Mediated Short Term Depression in Hippocampal Inhibition 

      Zachariou, Margarita; Alexander, S. P. H.; Coombes, S.; Christodoulou, Chris C. (2013)
      Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is ...
    • Article  

      Delivering nanomedicine to solid tumors 

      Jain, R. K.; Stylianopoulos, T. (2010)
      Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...
    • Article  

      Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies 

      Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)
      Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
    • Article  

      KIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner 

      Charalambous, Despina C.; Pasciuto, E.; Mercaldo, V.; Pilo Boyl, P.; Munck, S.; Bagni, C.; Santama, Niovi (2013)
      KIF1Bβ is a kinesin-like, microtubule-based molecular motor protein involved in anterograde axonal vesicular transport in vertebrate and invertebrate neurons. Certain KIF1Bβ isoforms have been implicated in different forms ...
    • Article  

      The origin of the Fe IV = O intermediates in cytochrome aa 3 oxidase 

      Pinakoulaki, Eftychia; Daskalakis, Vangelis; Varotsis, Constantinos (2012)
      The dioxygen reduction mechanism in cytochrome oxidases relies on proton control of the electron transfer events that drive the process. Proton delivery and proton channels in the protein that are relevant to substrate ...
    • Article  

      Targeting colon cancer cells with genistein-17.1A immunoconjugate. 

      Gentile, M. S.; Vasu, C.; Green, A.; Murillo, G.; Das Gupta, T. K.; Constantinou, Andreas I.; Prabhakar, B. S.; Salti, G. I. (2003)
      We have shown that genistein, a major component of soy, has anti-colon cancer effects in vitro. These effects are attainable at high concentrations that are difficult to achieve in the serum. The purpose of this study was ...