• Article  

      Cancer of unknown primary origin 

      Briassoulis, E. Ch; Pavlidis, Nicholas (1997)
      About 3 % of all cancer patients suffer from cancer of unknown primary origin. These patients present with metastatic disease for which a primary site cannot be detected at the time of diagnosis. Sophisticated diagnostic ...
    • Article  

      Cancer of unknown primary site 

      Pavlidis, Nicholas; Pentheroudakis, George (2012)
      Cancer of unknown primary site (CUP) is a well recognised clinical disorder, accounting for 3-5 of all malignant epithelial tumours. CUP is clinically characterised as an aggressive disease with early dissemination. ...
    • Article  

      The clinical picture of primary Sjogren's syndrome: A retrospective study 

      Pavlidis, Nicholas; Karsh, J.; Moutsopoulos, H. M. (1982)
      The clinical and laboratory features of 47 patients with primary Sjogren's syndrome, confirmed by lip biopsy, were analyzed in this study. The majority of our patients had the classical signs and symptoms of Sjogren's ...
    • Article  

      Computer-aided classification of breast cancer nuclei 

      Schnorrenberg, F.; Pattichis, Constantinos S.; Schizas, Christos N.; Kyriacou, Kyriacos C.; Vassiliou, M. (1996)
      Breast cancer is the most common malignancy affecting the female population in industrialized countries. Prognostic factors, such as steroid receptors visualized in biopsy slides, provide critical information to oncologists ...
    • Article  

      Evidence for activation of the unfolded protein response in collagen iv nephropathies 

      Pieri, Myrtani; Stefanou, Charalambos; Zaravinos, Apostolos; Erguler, K.; Stylianou, Konstantinos G.; Lapathitis, Georgios; Karaiskos, Christos; Savva, Isavella; Paraskeva, Revekka; Dweep, H.; Sticht, C.; Anastasiadou, Natassa; Zouvani, Ioanna; Goumenos, Dimitrios S.; Felekkis, Kyriacos N.; Saleem, M.; Voskarides, Konstantinos; Gretz, N.; Constantinou-Deltas, Constantinos D. (2014)
      Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and ...
    • Article  

      Familial C3 Glomerulopathy Associated with CFHR5 Mutations: Clinical Characteristics of 91 Patients in 16 Pedigrees 

      Athanasiou, Yiannis; Voskarides, Konstantinos; Gale, D. P.; Damianou, Loukas; Patsias, Charalambos; Zavros, Michalis; Maxwell, P. H.; Cook, H. T.; Demosthenous, Panayiota; Hadjisavvas, Andreas; Kyriacou, Kyriacos C.; Zouvani, Ioanna; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2011)
      Background and objectives Complement factor H and related proteins (CFHR) are key regulators of the alternative complement pathway, where loss of function mutations lead to a glomerulopathy with isolated mesangial C3 ...
    • Article  

      Improved detection of breast cancer nuclei using modular neural networks 

      Schnorrenberg, F.; Tsapatsoulis, Nicolas; Pattichis, Constantinos S.; Schizas, Christos N.; Kollias, S.; Vassiliou, M.; Adamou, Adamos K.; Kyriacou, Kyriacos C. (2000)
      A modular neural network-based approach to detect and classify breast cancer nuclei stained for steroid receptors in hispathological sections is evaluated. The system named biopsy analysis support system (BASS) is designed ...
    • Article  

      Liver metastases from cancer of unknown primary (CUPL): A retrospective analysis of presentation, management and prognosis in 49 patients and systematic review of the literature 

      Lazaridis, G.; Pentheroudakis, George; Fountzilas, George; Pavlidis, Nicholas (2008)
      Aim: Patients with liver metastases from cancer of unknown primary (CUPL) have a dismal prognosis. We retrospectively analysed their management and outcome and performed a systematic review of CUPL series published in the ...
    • Article  

      A morphological analysis of the macro motor unit potential 

      Pattichis, Constantinos S.; Schofield, I. S.; Fawcett, P. (1999)
      The technique of macro EMG is used to investigate the motor unit architecture in a number of pathological conditions. Amplitude and area are the most commonly used criteria, but these parameters alone are not sufficient ...
    • Article  

      Neglected cases of papillary and follicular thyroid carcinoma. Occurrence of subcutaneous scalp metastases 

      Pavlidis, Nicholas; Sourla, A.; Nikolaou, N.; Ch, F. Tolis; Mitsi, V. D. (1990)
      Three cases, two of follicular and one of papillary thyroid carcinoma are reported. All three patients presented with subcutaneous cystic scalp metastases; they had a long-standing history of thyroid cancer, although two ...
    • Article  

      A retrospective analysis of serum CA 15-3 concentrations in patients with localised or metastatic renal cancer and its impact on prognosis and follow-up. A single-centre experience 

      Briassoulis, E. Ch; Pentheroudakis, George; Letsa, I.; Pavlidis, Nicholas (2002)
      Background. Monitoring patients with renal cancer for recurrence or progression is ineffective, inconvenient and costly. We conducted a retrospective analysis of serum CA 15-3 concentrations in a single-centre patient ...
    • Article  

      Survivin and glycodelin transcriptional activity in node-positive early breast cancer: mRNA expression of two key regulators of cell survival 

      Kostadima, Lida; Pentheroudakis, George; Fountzilas, George; Dimopoulos, M. A.; Pectasides, Dimitrios; Gogas, H.; Christodoulou, C.; Samantas, E.; Bafaloukos, Dimitrios; Arapantoni, P.; Kalofonos, H. P.; Papakostas, P.; Economopoulos, T.; Bamias, A. T.; Pavlidis, Nicholas; Stropp, U.; Wirtz, R. M.; Hennig, G. (2006)
      Introduction: Glycodelin and survivin are key polypeptide regulators of cellular proliferation, apoptosis and angiogenesis. In view of contradictory reports on their functional role in tumors, we studied their transcriptional ...
    • Conference Object  

      Texture analysis of the endometrium during hysteroscopy: Preliminary results 

      Neophytou, Michael S.; Pattichis, Constantinos S.; Pattichis, Marios S.; Tanos, Vasilios; Kyriacou, Efthyvoulos C.; Pavlopoulos, Sotirios A.; Koutsouris, Demetrios Dionysios (2004)
      The objective of this study is to investigate the usefulness of texture analysis in the endometrium during hysteroscopy in endoscopic imaging of the uterine cavity. Endoscopy images from the endometrium from three subjects, ...
    • Article  

      Ultrastructural pathology of the heart in patients with beta-thalassaemia major 

      Kyriacou, Kyriacos; Michaelides, Y.; Senkus, R.; Simamonian, Krikor; Pavlidis, Nicholas; Antoniades, L.; Zambartas, C. (2000)
      Patients with beta-thalassaemia major frequently suffer from hypersiderosis which leads to hemochromatosis of major organs such as the heart and liver. Little information exists about the ultrastructural pathology of the ...