Browsing by Subject "Breast cancer"

Article

Activity and toxicity of GI147211 in breast, colorectal and non-small-cell lung cancer patients: An EORTC-ECSG phase II clinical study

Gamucci, T.; Paridaens, R.; Heinrich, B.; Schellens, J. H. M.; Pavlidis, Nicholas; Verweij, J.; Sessa, Cristiana; Kaye, Stanley B.; Roelvink, M.; Wanders, J.; Hanauske, A. R. (2000)

Background: GI147211 is a water-soluble synthetic analogue of camptothecin showing promising in vivo and in vitro antitumor activity and an acceptable toxicity profile. Patients and methods: Between April 1995 and November ...

Article

Adjuvant Cytotoxic and Endocrine Therapy in Pre- and Postmenopausal Patients with Breast Cancer and One to Nine Infiltrated Nodes: Five-Year Results of the Hellenic Cooperative Oncology Group Randomized HE 10/92 Study

Fountzilas, George; Stathopoulos, G. P.; Kouvatseas, G.; Polychronis, A.; Klouvas, G. D.; Samantas, E.; Zamboglou, N.; Kyriakou, K.; Adamou, A.; Pectasides, Dimitrios; Economopoulos, T.; Kalofonos, H. P.; Bafaloukos, Dimitrios; Georgoulias, V.; Razi, E. D.; Koukouras, D.; Zombolas, V.; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V.; Pavlidis, Nicholas (2004)

The present randomized phase III trial was designed to detect a 15% benefit in relapse-free survival (RFS) or overall survival (OS) from the incorporation of adjuvant tamoxifen to the combination of CNF [cyclophosphamide, ...

Article

Anxiety, depression and defense mechanisms associated with treatment decisional preferences and quality of life in non-metastatic breast cancer: A 1-year prospective study

Hyphantis, T.; Almyroudi, A.; Paika, V.; Degner, L. F.; Carvalho, A. F.; Pavlidis, Nicholas (2013)

Objective: Treatment decisional preferences impact breast cancer patients' health-related quality of life (HRQoL) and may relate to psychological variables, although many aspects of this relationship remain unknown. This ...

Article

Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes?

Liberopoulos, E. N.; Karabina, S. A.; Tselepis, A.; Bairaktari, Eleni Th; Nikolaides, C.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)

Background: Tamoxifen has favorable effects on the serum lipid profile. It has been suggested that the apolipoprotein (Apo) E phenotype can influence serum lipid parameters; the ApoE allele 4 (ApoE4) is associated with ...

Article

Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review

Zarkavelis, George; Kollas, Aristomenes; Kampletsas, E. O.; Vasiliou, V.; Kaltsonoudis, E.; Drosos, Alexandros A.; Khaled, H.; Pavlidis, Nicholas (2016)

Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. ...

Article

Association of Fokl and PvuII polymorphisms with breast cancer staging and survival among Caucasian women: A prospective study

Yiallourou, Anneza I.; Ekonomou, Emmanouel; Tsamadias, V.; Nastos, Constantinos; Karapanos, Konstantinos; Papaconstantinou, Ioannis; Theodosopoulos, Theodosios; Contis, John; Papalarabros, E.; Voros, Dionysios; Psychogios, J. (2014)

Purpose: Both vitamin D and estrogens play an important role in breast cell growth and differentiation. Therefore, we hypothesized that Fokl polymorphism in the Vitamin D Receptor (VDR) gene, as well as PvuII polymorphism ...

Article

Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer

Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)

Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...

Article

The beneficial effect of tamoxifen on serum lipoprotein-a levels: An additional anti-atherogenic property

Elisaf, Moses S.; Bairaktari, Eleni Th; Nikolaides, C.; Fountzilas, George; Tzallas, C. S.; Siamopoulos, K. C.; Tsolas, O.; Pavlidis, Nicholas (1996)

It has recently been suggested that increased lipoprotein (a) levels are an independent risk factor for coronary heart disease. It has also been reported that tamoxifen can induce changes in blood lipid values. In this ...

Article

Brain metastasis of unknown primary: A diagnostic and therapeutic dilemma

Polyzoidis, K. S.; Miliaras, G.; Pavlidis, Nicholas (2005)

The diagnosis of a brain metastasis is usually made during the routine follow up examinations of patients with known cancer, who are under the care of oncology departments. The involvement of the neurosurgeon depends on ...

Book Chapter

Breast Cancer Epigenetics

Pitta, Chara A.; Constantinou, Andreas I. (Elsevier Inc., 2015)

The molecular mechanisms underlying the development and progression of breast cancer are far from being understood. It is obvious that the initiation of breast cancer as well as its transition toward distinct breast cancer ...

Article

Cancer and pregnancy

Pavlidis, Nicholas (2000)

Article

Cancer and pregnancy: A comprehensive review

Voulgaris, E.; Pentheroudakis, George; Pavlidis, Nicholas (2011)

Background: Pregnancy complicated by cancer is relatively rare but, as women in western societies tend to delay childbearing to the third and fourth decade of life, this phenomenon is going to be encountered more often in ...

Article

Cancer and pregnancy: Poena magna, not anymore

Pentheroudakis, George; Pavlidis, Nicholas (2006)

Cancer diagnosed during pregnancy constitutes a difficult clinical condition with a devastating impact on the patient's somatic and psychosocial health and possibly on foetal integrity. This circumstance also raises several ...

Article

Cancer and pregnancy: What should we know about the management with systemic treatment of pregnant women with cancer?

Pavlidis, Nicholas (2011)

The incidence of cancer during pregnancy is a rare phenomenon and is estimated to occur in 1:1000 pregnancies. This co-existence is likely to rise since the delay of childbearing to the later reproductive age is nowadays ...

Article

Cancer of unknown primary site

Pavlidis, Nicholas; Pentheroudakis, George (2012)

Cancer of unknown primary site (CUP) is a well recognised clinical disorder, accounting for 3-5 of all malignant epithelial tumours. CUP is clinically characterised as an aggressive disease with early dissemination. ...

Article

Cancer of unknown primary site: 20 questions to be answered

Pavlidis, Nicholas; Pentheroudakis, George (2010)

Cancer of unknown primary (CUP) is a common, well-recognized and heterogeneous clinical syndrome. Patients with CUP present with metastatic disease in the absence of an identifiable primary tumour despite a diagnostic ...

Article

Cancer specific risk in multiple sclerosis patients

Kyritsis, A. P.; Boussios, Stergios; Pavlidis, Nicholas (2016)

Multiple sclerosis (MS) is a chronic central nervous system (CNS) autoimmune disease. Studies of cancer risk in MS patients have shown inconsistent findings. A pubmed search of the literature on cancer risk in patients ...

Article