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Browsing by Subject "Breast carcinoma"

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    • Article  

      The clinical significance of bcl-2 overexpression in breast cancer patients - A retrospective study with long term follow up 

      Bai, M. C.; Agnantis, Niki J.; Zagorianakou, P.; Kamina, S.; Nonni, A. V.; Pavlidis, Nicholas; Briassoulis, E. Ch (2001)
      We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. In 38.3% of the cases ...

    • Article  

      Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. Correlation with extracellular matrix components 

      Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Charchanti, A.; Damala, K.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)
      Syndecan-1, a cell surface proteoglycan found predominantly on epithelia of mature tissues, binds both extracellular matrix (ECM) components and basic fibroblast growth factor (bFGF) and is implicated in the restriction ...

    • Article  

      Effect of letrozole on the lipid profile in postmenopausal women with breast cancer 

      Elisaf, Moses S.; Bairaktari, Eleni Th; Nikolaides, C.; Kakaidi, B.; Tzallas, C. S.; Katsaraki, A.; Pavlidis, Nicholas (2001)
      Hormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase ...

    • Article  

      G-CSF induces elevation of circulating CA 15-3 in breast carcinoma patients treated in an adjuvant setting 

      Briassoulis, E. Ch; Andreopoulou, E.; Ch, F. Tolis; Bairaktari, Eleni Th; Katsaraki, A.; Dimopoulos, M. A.; Fountzilas, George; Seferiadis, C.; Pavlidis, Nicholas (2001)
      BACKGROUND. Cancer antigen 15-3 (CA 15-3), a circulating marker that determines secreted products of the polymorphic MUC1 gene, has been established as a convenient tool for monitoring breast carcinoma patients. METHODS. ...

    • Article  

      Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: A quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trial 

      Pentheroudakis, George; Kalogeras, K. T.; Wirtz, R. M.; Grimani, I.; Zografos, G.; Gogas, H.; Stropp, U.; Pectasides, Dimitrios; Skarlos, Dimosthenis V.; Hennig, G.; Samantas, E.; Bafaloukos, Dimitrios; Papakostas, P.; Kalofonos, H. P.; Pavlidis, Nicholas; Fountzilas, George (2009)
      Background Estrogen receptor (ER) and progesterone receptor (PgR) protein expression carry weak prognostic and moderate predictive utility for the outcome of early breast cancer patients on adjuvant chemohormonotherapy. ...

    • Article  

      Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: Their prognostic value and role in tumour invasion and progression 

      Ioachim, E.; Charchanti, A.; Briassoulis, E. Ch; Karavasilis, V.; Tsanou, E.; Arvanitis, D. L.; Agnantis, Niki J.; Pavlidis, Nicholas (2002)
      The immunohistochemical expression of the extracellular matrix (ECM) components tenascin (TN), fibronectin (FN), collagen type IV (Coll) and laminin (LN), and their possible relationships were studied in a series of 134 ...

    • Article  

      Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma 

      Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Damala, K.; Charchanti, A.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)
      The most important cellular protective mechanisms against oxidative stress are antioxidant enzymes. Their action is based on decomposal of reactive oxygen species (ROS) and their transformation to H2O2. Within the mitochondria ...

    • Article  

      Levels of absolute survival benefit for systemic therapies of advanced cancer: A call for standards 

      Ioannidis, J. P. A.; Pavlidis, Nicholas (2003)
      Research on systemic interventions in patients with advanced stage malignancies should be systematised with an emphasis on the absolute gain in survival for the median patient. Such information is most meaningful with ...

    • Article  

      Metastatic breast carcinoma confined to bone: Portrait of a clinical entity 

      Briassoulis, E. Ch; Karavasilis, V.; Kostadima, Lida; Ignatiadis, M.; Fountzilas, George; Pavlidis, Nicholas (2004)
      BACKGROUND. The current study was performed to study metastatic breast carcinoma that remains confined to bone. METHODS. The medical notes of 2514 breast carcinoma patients who were treated in 2 academic units over a 20-year ...

    • Article  

      Mitoxantrone: An active new agent in the treatment of advanced breast cancer 

      Stuart-Harris, R. C.; Bozek, T.; Pavlidis, Nicholas; Smith, I. E. (1984)
      Sixty-five patients with advanced breast carcinoma were treated with mitoxantrone, an anthracenedione with structural similarities to adriamycin. The series included 26 patients who had received no prior chemotherapy. ...

    • Article  

      The neutrophil, not the tumor: Serum CA 15-3 elevation as a result of granulocyte-colony-stimulating factor-induced neutrophil MUC1 overexpression and neutrophilia in patients with breast carcinoma receiving adjuvant chemotherapy 

      Pentheroudakis, George; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Damala, K.; Vassou, A.; Vartholomatos, G.; Kolaitis, N.; Pavlidis, Nicholas (2004)
      BACKGROUND. Patients with resected breast carcinoma who received granulocyte-colony-stimulating factor (G-CSF)-supported adjuvant chemotherapy exhibited an increase in their serum CA 15-3 levels. The authors investigated ...

    • Article  

      Oral chemotherapy in advanced breast cancer. A reconsideration 

      Pavlidis, Nicholas (1985)

    • Article  

      Phase II study of LU 103793 (dolastatin analogue) in patients with metastatic breast cancer 

      Kerbrat, P.; Dieras, V.; Pavlidis, Nicholas; Ravaud, A.; Wanders, J.; Fumoleau, P. (2003)
      LU 103793 is a synthetic analogue of Dolastatin 15 that inhibits tubulin polymerisation. The aim of this study was to evaluate the efficacy and tolerability of LU 103793 in patients with metastatic breast cancer who had ...

    • Article  

      The prognostic evaluation of tumor angiogenesis in invasive breast carcinoma 

      Ioachim, E.; Charchanti, A.; Charalabopoulos, K.; Tsanou, E.; Briassoulis, E. Ch; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2002)
      Microvessel density (MVD) was analyzed for associations with clinical and pathological factors as well as with other potential known prognostic factors such as: steroid receptor content (ER, PgR), p53 and proliferation ...

    • Article  

      The prognostic value of vascular endothelial growth factor (VEGF) in invasive breast cancer: Correlation with microvessel density (MVD), ER, PgR, p53 and proliferative associated indices (Ki-67, PCNA) 

      Ioachim, E.; Charchanti, A.; Briassoulis, E. Ch; Karavasilis, V.; Batsis, Ch; Pavlidis, Nicholas; Agnantis, Niki J. (2002)
      The formation of new vessels in both primary tumour and in metastasis induce various growth factors included the vascular endothelial growth factors (VEGF). The immunohistochemical expression of vascular endothelial growth ...

    • Article  

      Rectal metastases from lobular carcinoma of the breast: Report of a case and literature review 

      Bamias, A. T.; Baltayiannis, G.; Kamina, S.; Fatouros, M.; Lymperopoulos, E.; Agnantis, Niki J.; Tsianos, Epameinondas; Pavlidis, Nicholas (2001)
      Metastatic involvement of the gastrointestinal (G1) tract secondary to breast cancer is rare. Reported herein is the case of a 74-year-old woman with metastatic lobular breast carcinoma to the rectum presenting with ...

    • Article  

      Statistical modelling and prognostic analysis in primary breast carcinoma 

      Vonta, Filia; Karagrigoriou, Alex; Adamou, Adamos K.; Zouvani, Ioanna; Kyriacou, Kyriacos C. (2000)
      This work reports, for the first time, the results of the first retrospective study on breast cancer in Cyprus. The study which is based on 197 women with primary breast cancer who have undergone modified radical mastectomy ...

    • Article  

      Treatment for Patients With Unknown Primary Carcinoma and Unfavorable Prognostic Factors 

      Greco, F. A.; Pavlidis, Nicholas (2009)
      The treatment for patients with unknown primary carcinoma, particularly those with unfavorable prognosis factors, has changed in the last decade, and continues to evolve. Empiric chemotherapy trials reported since 2000 ...

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