Browsing by Subject "CANCER"
Now showing items 1-8 of 8
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Master Thesis
Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40
(2023-05-24)NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...
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Master Thesis Open Access
The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers
(2023-05-18)Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...
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Doctoral Thesis Open Access
In vitro investigation of the role of Ras Suppressor-1 (RSU-1) and Integrin-Linked kinase (ILK) in glioma progression and invasion
(Πανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering, 2019-12)Το πολύμορφο γλοιοβλάστωμα (Glioblastoma multiforme-GBM) είναι ο πιο επιθετικός τύπος καρκίνου του εγκεφάλου λόγω της ικανότητας των κυττάρων του να διεισδύουν σε γειτονικούς ιστούς. H μέση επιβίωση για τους ασθενείς είναι ...
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Master Thesis Open Access
Modelling Glioblastoma Angiogenesis in Drosophila larvae
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
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Doctoral Thesis Open Access
Mouse models for papillomavirus-mediated phenotypes
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2018-07)Οι HPV έχουν συσχετιστεί με την ανάπτυξη της πλειονότητας των καρκίνων του τραχήλου της μήτρας, καθώς και με ένα υποσύνολο καρκίνου κεφαλής και λαιμού, καρκίνο του δέρματος και άλλων καρκίνων της γενετικής περιοχής. Στόχος ...
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Master Thesis Open Access
The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...
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Master Thesis Open Access
Recombinant Poliovirus a therapeutic agent for Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05)Cancer is a leading cause of global mortality, and its burden is growing despite the availability of standard treatment methods. Genetically and Morphologically tumor cells differ from normal cells. However, cancers arise ...
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Doctoral Thesis
The role of innate immunity and stress signalling pathways in intestinal proliferation, endoreplication and tumorigenesis
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-05)Ο ανεξέλεγκτος κυτταρικός πολλαπλασιασμός και ο πολλαπλασιασμός του DNA που δεν συνοδεύεται από κυτταρική διαίρεση έχουν περιγραφεί εκτενώς στα καρκινικά κύτταρα. Δεδομένου ότι και τα δύο προαναφερθέντα φαινόμενα προκαλούνται ...