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Browsing by Subject "Cancer of unknown primary site"

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    • Article  

      Angiogenesis in cancer of unknown primary: Clinicopathological study of CD34, VEGF and TSP-1 

      Karavasilis, V.; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Tsanou, E.; Kitsou, E.; Kalofonos, H. P.; Fountzilas, George; Fotsis, T.; Pavlidis, Nicholas (2005)
      Background: Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge ...

    • Article  

      Axillary nodal metastases from carcinoma of unknown primary (CUPAx): A systematic review of published evidence 

      Pentheroudakis, George; Lazaridis, G.; Pavlidis, Nicholas (2010)
      Axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) represent a rare clinical entity without consensus on its biology, management and outcome. We systematically ...

    • Article  

      Cancer of unknown primary during pregnancy: An exceptionally rare coexistence 

      Pavlidis, Nicholas; Peccatori, Fedro A.; Lofts, F.; Greco, F. A. (2015)
      Background: Cancer in pregnancy is a rare disease with breast cancer, cervical cancer, melanoma and Hodgkin's disease to be the most commonly diagnosed malignancies during gestation. Cancer of unknown primary (CUP) is a ...

    • Article  

      Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer 

      Economopoulou, P.; Mountzios, G.; Pavlidis, Nicholas; Pentheroudakis, George (2015)
      Cancer of Unknown Primary (CUP) comprises a heterogeneous disease group with diagnosis of metastatic malignancy in the absence of an identifiable primary site after diagnostic work up. CUP may either resemble a specific ...

    • Article  

      Cancer of unknown primary patients with midline nodal distribution: Midway between poor and favourable prognosis? 

      Pentheroudakis, George; Stoyianni, A.; Pavlidis, Nicholas (2011)
      Background: Midline nodal cancer of unknown primary (CUP) has varying definitions and an unclear natural history compared to that of extragonadal germ cell cancer (EGCC) and neuroendocrine tumors. Methods: We systematically ...

    • Article  

      Cancer of unknown primary site 

      Pavlidis, Nicholas; Pentheroudakis, George (2012)
      Cancer of unknown primary site (CUP) is a well recognised clinical disorder, accounting for 3-5 of all malignant epithelial tumours. CUP is clinically characterised as an aggressive disease with early dissemination. ...

    • Article  

      Cancer of unknown primary site: 20 questions to be answered 

      Pavlidis, Nicholas; Pentheroudakis, George (2010)
      Cancer of unknown primary (CUP) is a common, well-recognized and heterogeneous clinical syndrome. Patients with CUP present with metastatic disease in the absence of an identifiable primary tumour despite a diagnostic ...

    • Article  

      Cancer of unknown primary site: Missing primary or missing biology? 

      Pentheroudakis, George; Briassoulis, E. Ch; Pavlidis, Nicholas (2007)
      Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer deaths and represents both a diagnostic and a management challenge. In CUP, the regression or dormancy of the primary tumor, the development ...

    • Article  

      Cancer of unknown primary: What kind of chemotherapy? what kind of disease? 

      Pentheroudakis, George; Pavlidis, Nicholas (2009)

    • Article  

      Cancers of unknown primary site: ESMO clinical practice guidelines for diagnosis, treatment and follow-up 

      Fizazi, K.; Greco, F. A.; Pavlidis, Nicholas; Pentheroudakis, George (2011)

    • Article  

      Cancers of unknown primary site: ESMO clinical practice guidelines for diagnosis, treatment and follow-up 

      Pavlidis, Nicholas; Briassoulis, E. Ch; Pentheroudakis, George (2010)

    • Article  

      Cancers of unknown primary site: ESMO clinical recommendation for diagnosis, treatment and follow-up 

      Briassoulis, E. Ch; Pavlidis, Nicholas; Felip, E. (2008)

    • Article  

      Cancers of unknown primary site: ESMO clinical recommendations for diagnosis, treatment and follow-up 

      Briassoulis, E. Ch; Pavlidis, Nicholas; Felip, E. (2009)

    • Article  

      Cancers of unknown primary site: ESMO Clinical Recommendations for diagnosis, treatment and follow-up 

      Briassoulis, E. Ch; Pavlidis, Nicholas (2007)

    • Article  

      Comparative survival with diverse chemotherapy regimens for cancer of unknown primary site: Multiple-treatments meta-analysis 

      Golfinopoulos, Vassilis; Pentheroudakis, George; Salanti, G.; Nearchou, A. D.; Ioannidis, J. P. A.; Pavlidis, Nicholas (2009)
      Objectives: To synthesize the evidence from randomized controlled trials concerning systemic treatment regimens for patients with cancer of unknown primary site (CUP). Data sources: PubMed and the Cochrane Library Central ...

    • Article  

      Docetaxel and carboplatin combination chemotherapy as outpatient palliative therapy in carcinoma of unknown primary: A multicentre Hellenic Cooperative Oncology Group phase II study 

      Pentheroudakis, George; Briassoulis, E. Ch; Kalofonos, H. P.; Fountzilas, George; Economopoulos, T.; Samelis, G.; Koutras, A. K.; Karina, M.; Xiros, N.; Samantas, E.; Bamias, A. T.; Pavlidis, Nicholas (2008)
      Introduction. Taxane/platinum combinations exhibit synergistic cytotoxicity and activity against a broad range of solid tumours. We sought to optimise the regimen as a suitable outpatient palliative treatment for cancer ...

    • Article  

      Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks 

      Kamposioras, K.; Pentheroudakis, George; Pavlidis, Nicholas (2013)
      Background: Cancer of unknown primary (CUP) ranks among the ten most common malignancies worldwide. Cancer of unknown primary presents as disseminated disease, has a dismal prognosis and remains a diagnosis of exclusion. ...

    • Article  

      Global microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors 

      Pentheroudakis, George; Spector, Y.; Krikelis, D.; Kotoula, V.; Meiri, E.; Malamou-Mitsi, Vassiliki D.; Fountzilas, George; Sanden, M.; Pavlidis, Nicholas; Benjamin, H.; Aharonov, R. (2013)
      No data exist on biologic differences between Cancer of unknown primary (CUP) and metastatic solid tumors of known primary site. We assigned a primary tissue of origin in 40 favorable CUP patients (A: serous peritoneal ...

    • Article  

      Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: Incidence, correlations and prognostic utility 

      Stoyianni, A.; Goussia, Anna; Pentheroudakis, George; Siozopoulou, V.; Ioachim, E.; Krikelis, D.; Golfinopoulos, Vassilis; Cervantes, A.; Bobos, M.; Fotsis, T.; Bellou, S.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)
      Background: The epithelial to mesenchymal transition (EMT) has been associated with metastatic dissemination and poor outcome in several solid tumour types. Our aim was to study its incidence and its prognostic significance ...

    • Article  

      Insights into the epithelial mesenchymal transition phenotype in cancer of unknown primary from a global microRNA profiling study 

      Stoyianni, A.; Pentheroudakis, George; Benjamin, H.; Cervantes, A.; Ashkenazi, K.; Lazaridis, G.; Pavlidis, Nicholas; Spector, Y. (2014)
      Purpose: We sought to study the microRNA regulation of epithelial mesenchymal transition (EMT), the acquisition of migratory, mesenchymal-like properties of epithelial cells, in cancer of unknown primary (CUP). Patients ...

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