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Browsing by Subject "Cancer prognosis"

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    • Article  

      Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: A Hellenic Cooperative Oncology Group study 

      Nikitas, N.; Karadimou, A.; Tsitoura, E.; Soupos, N.; Tsiatas, M.; Karavasilis, V.; Pectasides, Dimitrios; Pavlidis, Nicholas; Chrisofos, M.; Adamakis, I.; Murray, S.; Fountzilas, George; Dimopoulos, M. A.; Bamias, A. T. (2012)
      Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T ...

    • Article  

      Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes 

      Pentheroudakis, George; Kotoula, V.; Roock, W. De; Kouvatseas, G.; Papakostas, P.; Makatsoris, T.; Papamichael, D.; Xanthakis, I.; Sgouros, J.; Televantou, D.; Kafiri, G.; Tsamandas, A. C.; Razi, E. D.; Galani, E.; Bafaloukos, Dimitrios; Efstratiou, I.; Bompolaki, I.; Pectasides, Dimitrios; Pavlidis, Nicholas; Tejpar, S.; Fountzilas, George (2013)
      Background: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in order ...

    • Article  

      Cancer of unknown primary during pregnancy: An exceptionally rare coexistence 

      Pavlidis, Nicholas; Peccatori, Fedro A.; Lofts, F.; Greco, F. A. (2015)
      Background: Cancer in pregnancy is a rare disease with breast cancer, cervical cancer, melanoma and Hodgkin's disease to be the most commonly diagnosed malignancies during gestation. Cancer of unknown primary (CUP) is a ...

    • Article  

      Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer 

      Economopoulou, P.; Mountzios, G.; Pavlidis, Nicholas; Pentheroudakis, George (2015)
      Cancer of Unknown Primary (CUP) comprises a heterogeneous disease group with diagnosis of metastatic malignancy in the absence of an identifiable primary site after diagnostic work up. CUP may either resemble a specific ...

    • Article  

      Cancer of unknown primary site 

      Pavlidis, Nicholas; Pentheroudakis, George (2012)
      Cancer of unknown primary site (CUP) is a well recognised clinical disorder, accounting for 3-5 of all malignant epithelial tumours. CUP is clinically characterised as an aggressive disease with early dissemination. ...

    • Article  

      Depression in cancer: The many biobehavioral pathways driving tumor progression 

      Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)
      Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...

    • Article  

      Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials 

      Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)
      Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

    • Article  

      Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks 

      Kamposioras, K.; Pentheroudakis, George; Pavlidis, Nicholas (2013)
      Background: Cancer of unknown primary (CUP) ranks among the ten most common malignancies worldwide. Cancer of unknown primary presents as disseminated disease, has a dismal prognosis and remains a diagnosis of exclusion. ...

    • Article  

      Expression of E-cadherin in primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis of 30 cases 

      Varras, M.; Skafida, E.; Vasilakaki, T.; Anastasiadis, A.; Akrivis, C.; Vrachnis, N.; Nikolopoulos, Georgios K. (2013)
      Introduction: Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. Aim: The purpose of this study was to examine the distribution of E-cadherin ...

    • Article  

      Global microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors 

      Pentheroudakis, George; Spector, Y.; Krikelis, D.; Kotoula, V.; Meiri, E.; Malamou-Mitsi, Vassiliki D.; Fountzilas, George; Sanden, M.; Pavlidis, Nicholas; Benjamin, H.; Aharonov, R. (2013)
      No data exist on biologic differences between Cancer of unknown primary (CUP) and metastatic solid tumors of known primary site. We assigned a primary tissue of origin in 40 favorable CUP patients (A: serous peritoneal ...

    • Article  

      Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: Incidence, correlations and prognostic utility 

      Stoyianni, A.; Goussia, Anna; Pentheroudakis, George; Siozopoulou, V.; Ioachim, E.; Krikelis, D.; Golfinopoulos, Vassilis; Cervantes, A.; Bobos, M.; Fotsis, T.; Bellou, S.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)
      Background: The epithelial to mesenchymal transition (EMT) has been associated with metastatic dissemination and poor outcome in several solid tumour types. Our aim was to study its incidence and its prognostic significance ...

    • Article  

      Improved outcome of high-risk early HER2 positive breast cancer with high CXCL13-CXCR5 messenger RNA expression 

      Razi, E. D.; Kalogeras, K. T.; Kotoula, V.; Eleftheraki, A. G.; Nikitas, N.; Kronenwett, R.; Timotheadou, E.; Christodoulou, C.; Pectasides, Dimitrios; Gogas, H.; Wirtz, R. M.; Makatsoris, T.; Bafaloukos, Dimitrios; Aravantinos, Gerasimos; Televantou, D.; Pavlidis, Nicholas; Fountzilas, George (2012)
      Background: Chemokines are important in cell migration and are thought to play a key role in metastasis. We explored the prognostic significance of C-X-C ligand-motif (CXCL) 12, CXCL13, and receptor (CXCR) 5 on disease-free ...

    • Article  

      Intracellular signalling via the AKT axis and downstream effectors is active and prognostically significant in cancer of unknown primary (CUP): A study of 100 CUP cases 

      Golfinopoulos, Vassilis; Pentheroudakis, George; Goussia, Anna; Siozopoulou, V.; Bobos, M.; Krikelis, D.; Cervantes, A.; Ciuleanu, T.; Marselos, M.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)
      Background: Hypothesising that cancer of unknown primary (CUP) may harbour unique characteristics, we present a translational study of the immunohistochemical expression and clinical correlation of key PTEN/AKT pathway ...

    • Article  

      Long-term survivors among patients with cancer of unknown primary 

      Pavlidis, Nicholas; Petrakis, Dimitrios; Golfinopoulos, Vassilis; Pentheroudakis, George (2012)
      There is a general conception among oncologists that CUP patients behave poorly to treatment and carry a dismal survival. In this paper we are trying to elucidate the different groups of CUP patients and to describe in ...

    • Article  

      Mutational profiling of the RAS, PI3K, MET and b-catenin pathways in cancer of unknown primary: a retrospective study of the Hellenic Cooperative Oncology Group 

      Pentheroudakis, George; Kotteas, E. A.; Kotoula, V.; Papadopoulou, K.; Charalambous, E.; Cervantes, A.; Ciuleanu, T.; Fountzilas, George; Pavlidis, Nicholas (2014)
      Cancer of unknown primary origin (CUP) had a poor prognosis, determined by clinico-histological characteristics, partly due to the lack of insights on its biology. We screened tumour DNA from 87 patients with CUP for CTNNB1 ...

    • Article  

      Optimal therapeutic management of patients with distinct clinicopathological cancer of unknown primary subsets 

      Pavlidis, Nicholas (2012)
      Cancer of unknown primary sites (CUP) is a compilation of various malignant entities-the majority of which behave aggressively and carry poor prognosis. CUP is classified into two different clinicopathological groups: the ...

    • Article  

      Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary 

      Krikelis, D.; Pentheroudakis, George; Goussia, Anna; Siozopoulou, V.; Bobos, M.; Petrakis, Dimitrios; Stoyianni, A.; Golfinopoulos, Vassilis; Cervantes, A.; Ciuleanu, T.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)
      Cancer of unknown primary (CUP) is a heterogeneous entity, managed on the basis of "one size fits all" therapeutic concepts; insights into the molecular biology of CUP are urgently needed. We retrospectively examined the ...

    • Article  

      Prognosis of pregnancy-associated breast cancer: A meta-analysis of 30 studies 

      Jr, H. A. Azim; Santoro, L.; Russell-Edu, W.; Pentheroudakis, George; Pavlidis, Nicholas; Peccatori, Fedro A. (2012)
      Background: Pregnancy-associated breast cancer (PABC) is relatively rare with considerable controversy regarding its prognosis. Patients & methods: Two of the authors independently performed a literature search with no ...

    • Article  

      Prognostic factors in glioblastoma patients managed with radiotherapy combined with temozolomide 

      Peponi, Evangelia; Toumpoulis, Ioannis K.; Tasiou, I.; Pavlidis, Nicholas; Pentheroudakis, George; Tsekeris, P. (2014)
      Purpose: No consensus on clinicopathologic prognostic factors that predict the outcome of patients with newly diagnosed glioblastoma multiforme (GBM) managed with resection, postoperative radiotherapy (RT) and adjuvant ...

    • Article  

      Prognostic Significance of ESR1 Gene Amplification, mRNA/Protein Expression and Functional Profiles in High-Risk Early Breast Cancer: A Translational Study of the Hellenic Cooperative Oncology Group (HeCOG) 

      Pentheroudakis, George; Kotoula, V.; Eleftheraki, A. G.; Tsolaki, E.; Wirtz, R. M.; Kalogeras, K. T.; Batistatou, Anna; Bobos, M.; Dimopoulos, M. A.; Timotheadou, E.; Gogas, H.; Christodoulou, C.; Papadopoulou, K.; Efstratiou, I.; Scopa, C. D.; Papaspirou, I.; Vlachodimitropoulos, D.; Linardou, H.; Samantas, E.; Pectasides, Dimitrios; Pavlidis, Nicholas; Fountzilas, George (2013)
      Background:Discrepant data have been published on the incidence and prognostic significance of ESR1 gene amplification in early breast cancer.Patients and Methods:Formalin-fixed paraffin-embedded tumor blocks were collected ...

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