Browsing by Subject "Cell Division"

Article

The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCα

Tonetti, D. A.; Zhang, Y.; Zhao, H.; Lim, S. -B; Constantinou, Andreas I. (2007)

Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen ...

Article

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells

Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)

The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells

Article

Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice

Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)

Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

Article

Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture

Etcheverry, S. B.; Crans, D. C.; Keramidas, Anastasios D.; Cortizo, A. M. (1997)

Vanadium compounds mimic insulin actions in different cell types. The present study concerns the insulin-like effects of three vanadium(V) derivatives and one vanadium(IV) complex on osteoblast-like (UMR106 and MC3T3E1) ...

Article

Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells

Tonetti, D. A.; Rubenstein, R.; DeLeon, M.; Zhao, H.; Pappas, S. G.; Bentrem, D. J.; Chen, B.; Constantinou, Andreas I.; Jordan, V. C. (2003)

We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...

Article

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia

Apidianakis, Yiorgos; Pitsouli, Chrysoula; Perrimon, N.; Rahme, L. (2009)

Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasingly ...

Article

Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats

Burdette, J. E.; Liu, J.; Lantvit, D.; Lim, E.; Booth, N.; Bhat, K. P. L.; Hedayat, S.; Van Breemen, R. B.; Constantinou, Andreas I.; Pezzuto, J. M.; Farnsworth, N. R.; Bolton, J. L. (2002)

Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones ...