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Browsing by Subject "Clinical trials"

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    • Article  

      Biweekly administration of 24-h infusion of irinotecan followed by a 1-h infusion of docetaxel: A phase I study 

      Briassoulis, E. Ch; Pentheroudakis, George; Timotheadou, H.; Rammou, D.; Pavlidis, Nicholas; Fountzilas, George (2004)
      We developed a chemotherapy combination regimen based on preclinical data suggesting synchronization of cancer cells in G2/M phase when exposed to irinotecan over a protracted period. This phase I study aimed to determine ...

    • Article  

      Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials 

      Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)
      Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

    • Article  

      Immunization of patients with sjögren's syndrome with pneumococcal polysaccharide vaccine 

      Karsh, J.; Pavlidis, Nicholas; Schiffman, G.; Moutsopoulos, H. M. (1980)
      Thirty‐two patients with Sjögren's syndrome were randomly selected to receive either multivalent pneumococcal polysaccharide vaccine or saline placebo in a double‐blind study. Among placebo treated patients, levels of ...

    • Article  

      Major depressive disorder in breast cancer: A critical systematic review of pharmacological and psychotherapeutic clinical trials 

      Carvalho, A. F.; Hyphantis, T.; Sales, P. M. G.; Soeiro-de-Souza, M. G.; Macêdo, D. S.; Cha, D. S.; McIntyre, R. S.; Pavlidis, Nicholas (2014)
      Background: While women with breast cancer often face varying levels of psychological distress, there is a subgroup whose symptomatology reaches a threshold for diagnosis of major depressive disorder (MDD). Major depressive ...

    • Article  

      Non-small cell lung cancer in the young: A retrospective analysis of diagnosis, management and outcome data 

      Mauri, D.; Pentheroudakis, George; Bafaloukos, Dimitrios; Pectasides, Dimitrios; Samantas, E.; Efstathiou, E.; Kalofonos, H. P.; Syrigos, K.; Klouvas, G. D.; Papakostas, P.; Kosmidis, Paraskevas A.; Fountzilas, George; Pavlidis, Nicholas (2006)
      Background: Non-small cell lung cancer (NSCLC) in young patients is uncommon and is thought to constitute a distinct oncological entity with characteristic clinicopathological patterns. Since the reported data are scant ...

    • Article  

      Paclitaxel-carboplatin combination chemotherapy in advanced breast cancer: Accumulating evidence for synergy, efficacy, and safety 

      Pentheroudakis, George; Razi, E. D.; Athanasiades, A.; Pavlidis, Nicholas; Fountzilas, George (2006)
      Patients with metastatic breast cancer receive multiple lines of cytotoxic chemotherapy, with taxane and anthracycline-based regimens being the most active. Anthracyclines carry the risk of significant cardiotoxicity at ...

    • Article  

      Prognostic factors in Greek patients with small cell lung cancer (SCLC). A Hellenic Cooperative Oncology Group study 

      Christodoulou, C.; Pavlidis, Nicholas; Samantas, E.; Fountzilas, George; Kouvatseas, G.; Pagdatoglou, K.; Palamidas, F.; Nikolaides, C.; Angelidou, M.; Kalofonos, H. P.; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V. (2002)
      Background: Prognostic factors among Greek patients with SCLC were evaluated. Patients and Methods: Data from 516 patients with SCLC treated by the Hellenic Cooperative Oncology Group were analyzed. Multivariate analysis ...

    • Article  

      Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: A European consensus position paper 

      Casali, Paolo G.; Bruzzi, P.; Bogaerts, Jan; Blay, Jean-Yves; Aapro, M. S.; Adamou, A.; Berruti, A.; Bressington, J.; Bruzzi, B.; Capocaccia, R.; Cardoso, Fatima; Celis, J. E.; Cervantes, A.; Ciardiello, F.; Claussen, C.; Coleman, M.; Comis, S.; Craine, S.; Boltz, D. De; Lorenzo, F. De; P, Angelo Dei Tos; Gatta, G.; Geissler, J.; Giuliani, R.; Grande, E.; Gronchi, A.; Jezdic, S.; Jonsson, B.; Jost, Lorenz M.; Keulen, H.; Lacombe, D.; Lamory, G.; Cam, Y. Le; Priolo, S. Leto di; Licitra, Lisa; Macchia, F.; Margulies, A.; Marreaud, S.; McVie, G.; Narbutas, S.; Oliver, K.; Pavlidis, Nicholas; Pelouchova, J.; Pentheroudakis, George; Piccart, M.; Pierotti, M. A.; Pravettoni, G.; Redmond, K.; Riegman, P.; Ruffilli, M. P.; Ryner, D.; Sandrucci, S.; Seymour, M.; Torri, V.; Trama, A.; Belle, S. Van; Vassal, G.; Wartenberg, M.; Watts, C.; Wilson, A.; Yared, W. (2015)
      While they account for one-fifth of new cancer cases, rare cancers are difficult to study. A higher than average degree of uncertainty should be accommodated for clinical as well as for population-based decision making. ...

    • Article  

      Treatment of colorectal cancer in the elderly: A review of the literature 

      Golfinopoulos, Vassilis; Pentheroudakis, George; Pavlidis, Nicholas (2006)
      Although major progress has been achieved in the treatment of colorectal cancer, there are still several questions open for discussion concerning the management of elderly colorectal cancer patients. We conducted a review ...

    • Article  

      Triple-negative phenotype is of adverse prognostic value in patients treated with dose-dense sequential adjuvant chemotherapy: A translational research analysis in the context of a Hellenic Cooperative Oncology Group (HeCOG) randomized phase III trial 

      Skarlos, P.; Christodoulou, C.; Kalogeras, K. T.; Eleftheraki, A. G.; Bobos, M.; Batistatou, Anna; Valavanis, C.; Tzaida, O.; Timotheadou, E.; Kronenwett, R.; Wirtz, R. M.; Kostopoulos, I.; Televantou, D.; Koutselini, E.; Papaspirou, I.; Papadimitriou, C.; Pectasides, Dimitrios; Gogas, H.; Aravantinos, Gerasimos; Pavlidis, Nicholas; Arapantoni, P.; Skarlos, Dimosthenis V.; Fountzilas, George (2012)
      Purpose: It is well recognized that breast cancer is a heterogeneous disease. The purpose of the current study was to classify patients according to the immunohistochemical phenotype of their tumors in an effort to evaluate ...

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