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Browsing by Subject "Cohort studies"

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    • Article  

      Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. Correlation with extracellular matrix components 

      Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Charchanti, A.; Damala, K.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)
      Syndecan-1, a cell surface proteoglycan found predominantly on epithelia of mature tissues, binds both extracellular matrix (ECM) components and basic fibroblast growth factor (bFGF) and is implicated in the restriction ...

    • Article  

      The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis 

      Tsantes, Argirio E.; Tsangaris, I.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Kopterides, Petros; Antonakos, Georgios; Dimopoulou, Ioanna; Vrioni, G.; Kapsimali, Violetta; Dima, Kleanthi; Armaganidis, Apostolos; Travlou, Anthi S. (2010)
      Background. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis ...

    • Article  

      Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: Their prognostic value and role in tumour invasion and progression 

      Ioachim, E.; Charchanti, A.; Briassoulis, E. Ch; Karavasilis, V.; Tsanou, E.; Arvanitis, D. L.; Agnantis, Niki J.; Pavlidis, Nicholas (2002)
      The immunohistochemical expression of the extracellular matrix (ECM) components tenascin (TN), fibronectin (FN), collagen type IV (Coll) and laminin (LN), and their possible relationships were studied in a series of 134 ...

    • Article  

      Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma 

      Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Damala, K.; Charchanti, A.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)
      The most important cellular protective mechanisms against oxidative stress are antioxidant enzymes. Their action is based on decomposal of reactive oxygen species (ROS) and their transformation to H2O2. Within the mitochondria ...

    • Article  

      Impact of hepatitis B virus infection on the progression of AIDS and mortality in HIV-infected individuals: A cohort study and meta-analysis 

      Nikolopoulos, Georgios K.; Paraskeva, D.; Hatzitheodorou, E.; Moschidis, Zissis; Sypsa, V.; Zavitsanos, X.; Kalapothaki, Victoria; Hatzakis, A. (2009)
      Background. The effect of hepatitis B virus (HBV) infection on the natural history of human immunodeficiency virus (HIV) disease remains uncertain. Therefore, a retrospective cohort study was conducted to examine the ...

    • Article  

      KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: A cohort study 

      Negru, S.; Papadopoulou, E.; Apessos, A.; Stanculeanu, D. L.; Ciuleanu, E.; Volovat, C.; Croitoru, A.; Kakolyris, S.; Aravantinos, Gerasimos; Ziras, N.; Athanasiadis, E.; Touroutoglou, N.; Pavlidis, Nicholas; Kalofonos, H. P.; Nasioulas, G. (2014)
      Objectives: Treatment decision-making in colorectal cancer is often guided by tumour tissue molecular analysis. The aim of this study was the development and validation of a high-resolution melting (HRM) method for the ...

    • Article  

      Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: A meta-analysis 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsiara, Chrissa G.; Kapsimali, Violetta; Travlou, Anthi S.; Vaiopoulos, G. (2007)
      This study investigated the hypothesis that the insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor type-1 gene affects the risk for ischemic stroke, since results concerning this association ...

    • Article  

      Probing the unknown in cancer of unknown primary: Which way is the right way? 

      Pentheroudakis, George; Pavlidis, Nicholas (2010)

    • Article  

      Rapid Decline in HIV Incidence among Persons Who Inject Drugs during a Fast-Track Combination Prevention Program after an HIV Outbreak in Athens 

      Sypsa, V.; Psichogiou, M.; Paraskeva, D.; Nikolopoulos, Georgios K.; Tsiara, Chrissa G.; Paraskeva, D.; Micha, Katerina; Malliori-Minerva, Melpomeni; Pharris, Anastasia; Wiessing, L.; Donoghoe, Martin; Friedman, Samuel R.; Jarlais, Don Des; Daikos, Georgios L.; Hatzakis, A. (2017)
      Background. A "seek-test-treat" intervention (ARISTOTLE) was implemented in response to an outbreak of human immunodeficiency virus (HIV) infection among persons who inject drugs (PWID) in Athens. We assess trends in HIV ...

    • Article  

      A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational research study of the Hellenic Cooperative Oncology Group (HeCOG) 

      Pentheroudakis, George; Kotoula, V.; Fountzilas, E.; Kouvatseas, G.; Basdanis, G.; Xanthakis, I.; Makatsoris, T.; Charalambous, E.; Papamichael, D.; Samantas, E.; Papakostas, P.; Bafaloukos, Dimitrios; Razi, E. D.; Christodoulou, C.; Varthalitis, I.; Pavlidis, Nicholas; Fountzilas, George (2014)
      Background: Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor ...

    • Article  

      Switching benchmarks in cancer of unknown primary: From autopsy to microarray 

      Pentheroudakis, George; Golfinopoulos, Vassilis; Pavlidis, Nicholas (2007)
      Introduction: Cancer of unknown primary (CUP) is associated with unknown biology and dismal prognosis. Information on the primary site of origin is scant and has never been analysed. We systematically reviewed all published ...

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