Browsing by Subject "Colon cancer"

Article

Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer

Guo, J. -Y; Li, X.; Browning Jr., J. D.; Rottinghaus, G. E.; Lubahn, D. B.; Constantinou, Andreas I.; Bennink, M.; MacDonald, R. S. (2004)

Consumption of soy foods has been weakly associated with reduced colon cancer risk. Colon cancer risk is influenced by estrogen exposure, although the mechanism through which this occurs is not defined. Conversion of ...

Article

Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice

Murillo, G.; Choi, J. K.; Pan, O.; Constantinou, Andreas I.; Mehta, R. G. (2004)

Background: Epidemiological studies have reported a low incidence of colon cancer in countries with high legume consumption. Moreover, experimental studies have found that legumes, such as soybeans and pinto beans, have ...

Article

Fluorouracil and leucovorin with or without interferon alfa-2a as adjuvant treatment, in patients with high-risk colon cancer. A randomized phase III study conducted by the Hellenic Cooperative Oncology Group

Fountzilas, George; Zisiadis, A.; Dafni, U.; Konstantaras, C.; Hatzitheoharis, G.; Papavramidis, S.; Bousoulegas, A.; Basdanis, G.; Giannoulis, E.; Dokmetzioglou, J.; Katsohis, C.; Nenopoulou, E.; Karvounis, N.; Briassoulis, E. Ch; Aravantinos, Gerasimos; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V.; Pavlidis, Nicholas (2000)

Background: It has been shown in randomized studies that adjuvant treatment with the combination of fluorouracil (FU) and levamisole reduced the risk of recurrence and deaths of patients with stage III colon cancer. ...

Article

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells

Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)

The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells

Article

Long-term survivors among patients with cancer of unknown primary

Pavlidis, Nicholas; Petrakis, Dimitrios; Golfinopoulos, Vassilis; Pentheroudakis, George (2012)

There is a general conception among oncologists that CUP patients behave poorly to treatment and carry a dismal survival. In this paper we are trying to elucidate the different groups of CUP patients and to describe in ...

Article

Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: A systematic literature review

Pentheroudakis, George; Greco, F. A.; Pavlidis, Nicholas (2009)

Background: Gene expression profiling platforms were recently shown to accurately assign cancer of unknown primary (CUP) to a primary tissue of origin, with unknown impact on patient outcome. We examined chemotherapy ...

Article

Probing the unknown in cancer of unknown primary: Which way is the right way?

Pentheroudakis, George; Pavlidis, Nicholas (2010)

Article

Quantification of Tumor Microvascularity with Respiratory Gated Contrast Enhanced Ultrasound for Monitoring Therapy

Averkiou, Michalakis A.; Lampaskis, Marios; Kyriakopoulou, Konstantina; Skarlos, Dimosthenis; Klouvas, Georgios; Strouthos, Costas; Leen, Edward (2010)

Abstract: The aim of this feasibility study was to evaluate the response to cytotoxic and antiangiogenic treatment of colorectal liver metastasis using respiratory gated contrast enhanced ultrasonography. Seven patients ...

Article

A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational research study of the Hellenic Cooperative Oncology Group (HeCOG)

Pentheroudakis, George; Kotoula, V.; Fountzilas, E.; Kouvatseas, G.; Basdanis, G.; Xanthakis, I.; Makatsoris, T.; Charalambous, E.; Papamichael, D.; Samantas, E.; Papakostas, P.; Bafaloukos, Dimitrios; Razi, E. D.; Christodoulou, C.; Varthalitis, I.; Pavlidis, Nicholas; Fountzilas, George (2014)

Background: Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor ...

Article

Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2012)

Background: Fibrates comprise a class of well-established antilipidemic agents that significantly reduce cardiovascular events. Given the concerns of cancer with fibrate therapy, we undertook a systematic review and ...