Browsing by Subject "Desmoplasia"
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Article
Cell adhesion and matrix stiffness: Coordinating cancer cell invasion and metastasis
(2018)Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's adhesome at cell-ECM adhesion sites and ...
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Article
Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
(2015)Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of ...
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Article
Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion
(2018)Background: Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including ...