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Browsing by Subject "Drosophila"

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    • Article  

      Drosophila and the hallmarks of cancer 

      Christofi, T.; Apidianakis, Yiorgos (2013)
      : Cancer was the disease of the twentieth century. Today it is still a leading cause of death worldwide despite being intensively investigated. Abundant knowledge exists regarding the pathological and molecular mechanisms ...

    • Doctoral Thesis  

      Ecological and biological responses to environmental changes, in the endemic scleractinian coral, Cladocora caespitosa (Linnaeus, 1767), in Cyprus 

      Hadjioannou, Louis M. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-10)
      Η παρούσα διατριβή διερευνά τις οικολογικές και βιολογικές αποκρίσεις του μεσογειακού κοραλλιού Cladocora caespitosa, σε περιβαλλοντικές αλλαγές. Το σκληρακτήνιο αυτό είδος κοραλλιού, το οποίο χτίζει αποικίες, έχει ανομοιότυπη ...

    • Article  

      Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila 

      Ligoxygakis, P.; Bray, S. J.; Apidianakis, Yiorgos; Delidakis, Christos (1999)
      A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors. ...

    • Article  

      Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis 

      Pitsouli, Chrysoula; Perrimon, N. (2010)
      Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...

    • Article  

      Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes 

      Markstein, M.; Pitsouli, Chrysoula; Villalta, C.; Celniker, S. E.; Perrimon, N. (2008)
      A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...

    • Article  

      FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases 

      Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, Savvas N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. (2009)
      Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...

    • Article  

      Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch 

      Apidianakis, Yiorgos; Grbavec, D.; Stifani, S.; Delidakis, Christos (2001)
      Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...

    • Article  

      Hedgehog restricts its expression domain in the Drosophila wing 

      Bejarano, F.; Pérez, L.; Apidianakis, Yiorgos; Delidakis, Christos; Milán, M. (2007)
      The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...

    • Article  

      The homeobox transcription factor cut coordinates patterning and growth during drosophila airway remodeling 

      Pitsouli, Chrysoula; Perrimon, N. (2013)
      A fundamental question in developmental biology is how tissue growth and patterning are coordinately regulated to generate complex organs with characteristic shapes and sizes. We showed that in the developing primordium ...

    • Article  

      Homeostasis in Infected Epithelia: Stem Cells Take the Lead 

      Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)
      To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...

    • Article  

      Human pathogenic bacteria, fungi, and viruses in Drosophila 

      Panayidou, S.; Ioannidou, E.; Apidianakis, Yiorgos (2014)
      Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, ...

    • Article  

      Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells 

      Bangi, E.; Pitsouli, Chrysoula; Rahme, L. G.; Cagan, R.; Apidianakis, Yiorgos (2012)
      Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...

    • Article  

      The interplay between DSL proteins and ubiquitin ligases in Notch signaling 

      Pitsouli, Chrysoula; Delidakis, Christos (2005)
      Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was ...

    • Doctoral Thesis  

      Investigating the role of pseudomonas aeruginosa metabolism in virulence 

      Panayidou, Stavria P. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-12)
      Η τρέχουσα παγκόσμια τάση αντοχής στα αντιβιοτικά απαιτεί νέες προσεγγίσεις για αντιμολυσματική θεραπεία. Η ψευδομονάδα (Pseudomonas aeruginosa), είναι ένα Gram-αρνητικό βακτήριο που ταξινομείται μεταξύ των παθογόνων πρώτης ...

    • Article  

      Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila 

      Vinegoni, C.; Razansky, D.; Pitsouli, Chrysoula; Perrimon, N.; Ntziachristos, V.; Weissleder, R. (2009)
      Visualizing developing organ formation as well as progession and treatment of disease often heavily relies on the ability to optically interrogate molecular and functional changes in intact living organisms. Most existing ...

    • Article  

      Neural hyperplasia induced by RNA interference with m4/mα gene activity 

      Nagel, A. C.; Apidianakis, Yiorgos; Wech, I.; Maier, D.; Delidakis, Christos; Preiss, A. (2000)
      The E(spl) complex (E(spl)-C) contains three different classes of genes that are downstream of Notch signaling. The bHLH genes mediate the Notch signal by repressing proneural gene activity, for example during the ...

    • Article  

      Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition 

      Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)
      Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

    • Article  

      Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer 

      Markou, P.; Apidianakis, Yiorgos (2014)

    • Doctoral Thesis  

      Pseudomonas aeruginosa interactions with its host and with commensal escherichia coli 

      Christofi, Theodoulakis Ch. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2018–10)
      Το ανθρώπινο μικροβίωμα αποτελείται από μικροοργανισμούς που φιλοξενούνται σε διάφορα μέρη του ανθρώπινου σώματος. Περιοχές που έρχονται σε επαφή με το περιβάλλον ή με την καταναλωθέντα τροφή όπως, το δέρμα, το αναπνευστικό ...

    • Article  

      A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes 

      Kesarwani, M.; Hazan, R.; He, J.; Que, Y.; Apidianakis, Yiorgos; Lesic, B.; Xiao, G.; Dekimpe, V.; Milot, S.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2011)
      A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial ...

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