Browsing by Subject "Drosophila"

Article

Drosophila and the hallmarks of cancer

Christofi, T.; Apidianakis, Yiorgos (2013)

: Cancer was the disease of the twentieth century. Today it is still a leading cause of death worldwide despite being intensively investigated. Abundant knowledge exists regarding the pathological and molecular mechanisms ...

Doctoral Thesis

Ecological and biological responses to environmental changes, in the endemic scleractinian coral, Cladocora caespitosa (Linnaeus, 1767), in Cyprus

Hadjioannou, Louis M. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-10)

Η παρούσα διατριβή διερευνά τις οικολογικές και βιολογικές αποκρίσεις του μεσογειακού κοραλλιού Cladocora caespitosa, σε περιβαλλοντικές αλλαγές. Το σκληρακτήνιο αυτό είδος κοραλλιού, το οποίο χτίζει αποικίες, έχει ανομοιότυπη ...

Article

Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila

Ligoxygakis, P.; Bray, S. J.; Apidianakis, Yiorgos; Delidakis, Christos (1999)

A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors. ...

Article

Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis

Pitsouli, Chrysoula; Perrimon, N. (2010)

Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...

Article

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes

Markstein, M.; Pitsouli, Chrysoula; Villalta, C.; Celniker, S. E.; Perrimon, N. (2008)

A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...

Article

FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases

Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, Savvas N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. (2009)

Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...

Article

Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch

Apidianakis, Yiorgos; Grbavec, D.; Stifani, S.; Delidakis, Christos (2001)

Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...

Article

Hedgehog restricts its expression domain in the Drosophila wing

Bejarano, F.; Pérez, L.; Apidianakis, Yiorgos; Delidakis, Christos; Milán, M. (2007)

The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...

Article

The homeobox transcription factor cut coordinates patterning and growth during drosophila airway remodeling

Pitsouli, Chrysoula; Perrimon, N. (2013)

A fundamental question in developmental biology is how tissue growth and patterning are coordinately regulated to generate complex organs with characteristic shapes and sizes. We showed that in the developing primordium ...

Article

Homeostasis in Infected Epithelia: Stem Cells Take the Lead

Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)

To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...

Article

Human pathogenic bacteria, fungi, and viruses in Drosophila

Panayidou, S.; Ioannidou, E.; Apidianakis, Yiorgos (2014)

Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, ...

Article

Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells

Bangi, E.; Pitsouli, Chrysoula; Rahme, L. G.; Cagan, R.; Apidianakis, Yiorgos (2012)

Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...

Article

The interplay between DSL proteins and ubiquitin ligases in Notch signaling

Pitsouli, Chrysoula; Delidakis, Christos (2005)

Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was ...

Doctoral Thesis

Investigating the role of pseudomonas aeruginosa metabolism in virulence

Panayidou, Stavria P. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-12)

Η τρέχουσα παγκόσμια τάση αντοχής στα αντιβιοτικά απαιτεί νέες προσεγγίσεις για αντιμολυσματική θεραπεία. Η ψευδομονάδα (Pseudomonas aeruginosa), είναι ένα Gram-αρνητικό βακτήριο που ταξινομείται μεταξύ των παθογόνων πρώτης ...

Article

Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila

Vinegoni, C.; Razansky, D.; Pitsouli, Chrysoula; Perrimon, N.; Ntziachristos, V.; Weissleder, R. (2009)

Visualizing developing organ formation as well as progession and treatment of disease often heavily relies on the ability to optically interrogate molecular and functional changes in intact living organisms. Most existing ...

Article

Neural hyperplasia induced by RNA interference with m4/mα gene activity

Nagel, A. C.; Apidianakis, Yiorgos; Wech, I.; Maier, D.; Delidakis, Christos; Preiss, A. (2000)

The E(spl) complex (E(spl)-C) contains three different classes of genes that are downstream of Notch signaling. The bHLH genes mediate the Notch signal by repressing proneural gene activity, for example during the ...

Article

Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition

Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

Article

Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer

Markou, P.; Apidianakis, Yiorgos (2014)

Doctoral Thesis

Pseudomonas aeruginosa interactions with its host and with commensal escherichia coli

Christofi, Theodoulakis Ch. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2018–08)

Το ανθρώπινο μικροβίωμα αποτελείται από μικροοργανισμούς που φιλοξενούνται σε διάφορα μέρη του ανθρώπινου σώματος. Περιοχές που έρχονται σε επαφή με το περιβάλλον ή με την καταναλωθέντα τροφή όπως, το δέρμα, το αναπνευστικό ...

Article

A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes

Kesarwani, M.; Hazan, R.; He, J.; Que, Y.; Apidianakis, Yiorgos; Lesic, B.; Xiao, G.; Dekimpe, V.; Milot, S.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2011)

A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial ...